Abstract | BACKGROUND AND OBJECTIVES: METHODS: RESULTS: Seven hundred sixty-nine incident AF cases were recorded during a follow-up of 21.3 years. Individuals with high levels of IgM against native p210 at baseline had a lower risk of developing AF; however, the association did not remain after adjustment for age and sex. Women had higher levels of IgM against native p210 than men (0.70 ± 0.22 AU vs. 0.63 ± 0.21 AU, p < 0.001). The association of IgM against native p210 and AF was significantly different between sexes (p for interaction = 0.024), where females with high IgM against p210 had a lower risk for incidence of AF (hazard ratio [95% confidence interval] 4th versus 1st quartile: 0.67 [0.49-0.91]; p = 0.01) after adjusting for risk factors and comorbidities. CONCLUSION: These findings support an association of humoral autoimmunity with AF.
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Authors | Kari Anne Sveen, Gustav Smith, Harry Björkbacka, Marju Orho-Melander, Gunnar Engström, Isabel Gonçalves, Olle Melander, Jan Nilsson, Eva Bengtsson |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 291
Issue 2
Pg. 207-217
(02 2022)
ISSN: 1365-2796 [Electronic] England |
PMID | 34532909
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Association for the Publication of the Journal of Internal Medicine. |
Chemical References |
- Apolipoprotein B-100
- Autoantibodies
- Immunoglobulin G
- Immunoglobulin M
|
Topics |
- Apolipoprotein B-100
(immunology)
- Atrial Fibrillation
(epidemiology)
- Autoantibodies
(blood)
- Female
- Humans
- Immunoglobulin G
(blood)
- Immunoglobulin M
(blood)
- Incidence
- Inflammation
- Male
- Risk Factors
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