Obesity, generally characterized by excessive
lipid accumulation, is a metabolic threat worldwide due to its rapid growth in global prevalence.
Ginsenosides are crucial components derived from natural plants that can confer metabolic benefits for obese patients. Considering the low bioavailability and degradable properties of
ginsenosides in vivo, it should be admitted that the mechanism of
ginsenosides on anti-
obesity contribution is still obscure. Recently, studies have indicated that
ginsenoside intervention has beneficial metabolic effects on
obesity and its complications because it allows for the correction of gut microbiota
dysbiosis and regulates the secretion of related endogenous metabolites. In this review, we summarize the role of gut microbiota in the pathogenetic process of
obesity, and explore the mechanism of
ginsenosides for ameliorating
obesity, which can modulate the composition of gut microbiota by improving the metabolism of intestinal endogenous substances and alleviating the level of
inflammation.
Ginsenosides are expected to become a promising anti-
obesity medical intervention in the foreseeable clinical settings.