Abstract | BACKGROUND: METHODS: We included 87,053 Japanese individuals who completed a food frequency questionnaire and were followed up from 1995-1998 to 2013 and 2015. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by Cox proportional-hazard regression across quintiles of dietary intakes of B vitamins and methionine. RESULTS: After 1,456,678 person-years of follow-up, 427 EC cases were documented. The multivariable HR (95% CI) of incident EC in the highest versus lowest quintile of dietary intake of vitamin B12 was 1.75 (1.13-2.71; p-trend=0.01). Stratification analysis based on alcohol consumption showed that higher dietary intakes of vitamin B12 and methionine were associated with an increased risk of EC among never-drinkers; HRs (95% CIs) were 2.82 (1.18-6.74; p-trend=0.009; p-interaction=0.18) and 3.45 (1.32-9.06; p-trend=0.003; p-interaction 0.02) for vitamin B12 and methionine, respectively. Meanwhile, there was no association between vitamin B12 and methionine intake with the risk of EC among drinkers. There were no associations between dietary intake of folate or vitamin B6 and the risk of EC. CONCLUSION: Dietary intake of vitamin B12 was positively associated with the risk of EC in the Japanese population.
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Authors | Paramita Khairan, Tomotaka Sobue, Ehab Salah Eshak, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Taichi Shimazu, Hiroyasu Iso, Shoichiro Tsugane |
Journal | BMC cancer
(BMC Cancer)
Vol. 21
Issue 1
Pg. 982
(Sep 01 2021)
ISSN: 1471-2407 [Electronic] England |
PMID | 34470601
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Vitamins
- Vitamin B 6
- Folic Acid
- Methionine
- Vitamin B 12
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Topics |
- Aged
- Alcohol Drinking
(physiopathology)
- Eating
- Esophageal Neoplasms
(epidemiology, metabolism)
- Female
- Folic Acid
(administration & dosage)
- Follow-Up Studies
- Humans
- Japan
(epidemiology)
- Male
- Methionine
(administration & dosage)
- Middle Aged
- Prognosis
- Prospective Studies
- Public Health
- Risk Factors
- Vitamin B 12
(administration & dosage)
- Vitamin B 6
(administration & dosage)
- Vitamins
(administration & dosage)
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