Tumor markers and 18F-FDG PET/CT after orchiectomy in seminoma: Is there any correlation?

Abstract

OBJECTIVE:

The aim of our study was to analyze the potential relationship between tumor markers and 18F-fluorodoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) results in patients affected by seminoma.

MATERIAL AND METHODS:

65 18F-FDG PET/CT scans of 41 patients with diagnosis of seminoma were analyzed and compared to alpha-fetoprotein (AFP) and human chorionic gonadotropin (hCG). PET/CT studies were analyzed qualitatively and measuring the maximum and mean standardized uptake value body weight max (SUVbwmax, SUVbwmean), maximum SUV lean body mass (SUVlbm), maximum SUV body surface area (SUVbsa), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of hypermetabolic lesions. All values were compared with serum markers.

RESULTS:

31 PET/CT studies were true negative, 28 true positive, 6 false positive and 0 false negative with sensitivity of 100%, specificity of 84%, negative predictive value of 100%, positive predictive value of 82% and accuracy of 91%. No correlation between PET results and tumor marker levels was found and also between AFP and PET/CT semiquantitive parameters. All semiquantitative PET parameters were significantly related to hCG level.

CONCLUSIONS:

18F-FDG PET/CT has good accuracy in evaluating patients with relapsed seminoma. HCG levels were significantly correlated with metabolic PET/CT parameters.

• Authors: Francesco Dondi, Domenico Albano, Francesco Bertagna, Raffaele Giubbini
• Journal: Revista espanola de medicina nuclear e imagen molecular (Rev Esp Med Nucl Imagen Mol (Engl Ed)) 2021 Sep-Oct Vol. 40 Issue 5 Pg. 287-292 ISSN: 2253-8089 [Electronic] Spain
• PMID: 34425969 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Sociedad Española de Medicina Nuclear e Imagen Molecular. Published by Elsevier España, S.L.U. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Chorionic Gonadotropin
• Radiopharmaceuticals
• alpha-Fetoproteins
• Fluorodeoxyglucose F18

Topics

• Adult
• Biomarkers, Tumor (blood)
• Chorionic Gonadotropin (blood)
• Fluorodeoxyglucose F18
• Glycolysis
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (blood, diagnostic imaging)
• Orchiectomy
• Positron Emission Tomography Computed Tomography
• Predictive Value of Tests
• Radiopharmaceuticals
• Retrospective Studies
• Seminoma (blood, diagnostic imaging, pathology, surgery)
• Testicular Neoplasms (blood, diagnostic imaging, pathology, surgery)
• Tumor Burden
• Young Adult
• alpha-Fetoproteins (analysis)