Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation.
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| Abstract |
Psoriasis is a common immune-mediated, chronic, inflammatory skin disease that affects approximately 2-3% of the population worldwide. Although there is increasing evidence regarding the essential roles of the interleukin (IL)-23/IL-17 axis and dendritic cell (DC)-T cell crosstalk in the development of skin inflammation, the contributions of mitochondrial function to psoriasis are unclear. In a mouse model of imiquimod (IMQ)-induced psoriasiform skin inflammation, we found that hematopoietic cell-specific genetic deletion of p32/C1qbp, a regulator of mitochondrial protein synthesis and metabolism, protects mice from IMQ-induced psoriatic inflammation. Additionally, we demonstrate that p32/C1qbp is an important regulator of IMQ-induced DC activation, both in vivo and in vitro. We also found that p32/C1qbp-deficient DCs exhibited impaired production of IL-1β, IL-23, and mitochondrial reactive oxygen species (mtROS) after IMQ stimulation. Because the inhibition of mtROS suppressed IMQ-induced DC activation and psoriatic inflammation, we presume that p32/C1qbp and mtROS can serve as therapeutic targets in psoriasis.
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| Authors | Soichi Mizuguchi, Kazuhito Gotoh, Yuya Nakashima, Daiki Setoyama, Yurie Takata, Shouichi Ohga, Dongchon Kang |
| Journal | Frontiers in immunology (Front Immunol) Vol. 12 Pg. 714897 ( 2021) ISSN: 1664-3224 [Electronic] Switzerland |
| PMID | 34421919 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2021 Mizuguchi, Gotoh, Nakashima, Setoyama, Takata, Ohga and Kang. |
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