The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity.

Abstract

Platelet-activating factor (PAF) in a concentration of 10(-11) mole per animal decreased the threshold doses for onsets of arrhythmia, ventricular flutters and fibrillation in ouabain induced arrhythmia in guinea-pigs in a statistically significant manner. The specific PAF antagonist BN 52021 (20 mg/kg, orally) completely inhibited the PAF effect for all types of arrhythmia, while the Ca2+ antagonistic drug diltiazem (0.1 mg/kg, i.v.) failed to counteract the PAF action. BN 52021 (20 mg/kg, per os) alone did not exert any effect on ouabain induced arrhythmia, but as expected, diltiazem (0.1 mg/kg, i.v.) showed antiarrhythmic effects. These results confirm the specific PAF antagonistic activity of BN 52021, its usefulness for PAF related cardiac rhythm disturbances and indicate that the method used could be a further useful tool to screen PAF antagonistic substances.

• Authors: A Riedel, P Braquet, H J Mest
• Journal: Pharmacological research communications (Pharmacol Res Commun) Vol. 19 Issue 10 Pg. 703-12 (Oct 1987) ISSN: 0031-6989 [Print] United States
• PMID: 3441484 (Publication Type: Journal Article)

Chemical References

• Diterpenes
• Ginkgolides
• Lactones
• Platelet Activating Factor
• Ouabain
• ginkgolide B
• Diltiazem

Topics

• Administration, Oral
• Animals
• Arrhythmias, Cardiac (chemically induced, physiopathology)
• Diltiazem (pharmacology)
• Diterpenes
• Ginkgolides
• Guinea Pigs
• In Vitro Techniques
• Injections, Intravenous
• Lactones (administration & dosage, pharmacology)
• Ouabain (pharmacology)
• Platelet Activating Factor (antagonists & inhibitors)