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Diltiazem (Cardizem)

A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
Also Known As:
Cardizem; Diltiazem Hydrochloride; Aldizem; CRD-401; Cardil; Dilacor; Dilacor XR; Dilren; Diltiazem Malate; Dilzem; Tiazac; CRD 401; CRD401; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
Networked: 2789 relevant articles (415 outcomes, 533 trials/studies)

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Drug Context: Research Results

Experts

1. Melander, Olle: 7 articles (10/2018 - 07/2008)
2. Hedner, Thomas: 6 articles (08/2013 - 01/2002)
3. Semsarian, Christopher: 5 articles (11/2016 - 04/2002)
4. Wahlstrand, Björn: 4 articles (08/2013 - 07/2008)
5. Bakris, George L: 4 articles (01/2013 - 03/2004)
6. Glasser, Stephen P: 4 articles (02/2009 - 01/2003)
7. Albert, Kenneth S: 4 articles (02/2005 - 01/2003)
8. Boden, W E: 4 articles (05/2001 - 05/2000)
9. DeMott, Joshua M: 3 articles (01/2021 - 01/2018)
10. Peksa, Gary D: 3 articles (01/2021 - 01/2018)

Related Diseases

1. Stable Angina
2. Hypertension (High Blood Pressure)
3. Atrial Fibrillation
4. Ischemia
03/01/1990 - "Thus, it is concluded that 1) diltiazem infusion significantly enhanced recovery of segmental systolic thickening after 15 min of ischemia and 24 h of reperfusion; 2) the enhancement in segmental systolic function could not entirely be attributed to decreased mean arterial pressure; 3) improvement in postischemic segmental ventricular function was seen only in those segments with systolic thinning during ischemia; thus, segments with the most severe ischemic dysfunction benefited most; and 4) there were no important differences in regional myocardial blood flow during ischemia and reperfusion between saline- and diltiazem-treated animals."
02/01/1996 - "For 30 min global ischemia, the addition of diltiazem to STS significantly improved the percentage recovery ratio of aortic flow (63.2 +/- 8.6% vs 79.9 +/- 5.9%, control vs. diltiazem, p < 0.01) and reduced CPK leakage during reperfusion (87.5 +/- 35.8 IU/20 min/g dry wt vs. 41.7 +/- 14.5 IU/20 min/g dry wt, control vs. diltiazem, p < 0.05). "
03/01/1992 - "Addition of diltiazem (0.8 microM) before subjecting hearts to a 30-min period of global no-flow ischemia resulted in a significant improvement in recovery of mechanical function (heart rate x developed pressure during reperfusion recovered to 28 and 53% of preischemic levels, in control and diltiazem-treated hearts, respectively). "
11/01/1989 - "Pre- and postischemic treatment with diltiazem led to significant improvement of CPFP in the OM: 4.9% of tissue areas were lying more than 60 microns from the next perfused capillary vs 70.2% after untreated ischemia. "
01/01/1988 - "Thus, diltiazem affords substantial protection against both early ischemia-induced ventricular arrhythmias and reperfusion-induced arrhythmias and this action may be associated with the beneficial effects on ischemia-induced ST segment elevation."
5. Angina Pectoris

Related Drugs and Biologics

1. Verapamil (Calan)
2. Nifedipine (Adalat)
3. Calcium
4. Calcium Channel Blockers (Blockers, Calcium Channel)
5. Nitroglycerin (Dynamite)
6. Propranolol (Inderal)
7. Metoprolol (Toprol-XL)
8. Antihypertensive Agents (Antihypertensives)
9. Digoxin (Digitek)
10. Hydrochlorothiazide (Esidrix)

Related Therapies and Procedures

1. Therapeutics
2. Hemorrhoidectomy
3. Intravenous Infusions
4. Sphincterotomy
5. Controlled Hypotension