Cutaneous non-tuberculous mycobacterial (NTM)
infections are an
emerging infectious disease and require a protracted course of combination
antibiotics. Antimicrobial choice is limited by resistance and toxicity.
Tedizolid is a new
oxazolidinone antibiotic with in vitro activity against some NTM, but its use in the management of extrapulmonary NTM has not been described. We report on the utility of prolonged
tedizolid use (8 months), after
linezolid intolerance, in combination
therapy in a case of difficult Mycobacterium chelonae cutaneous
infection. Although
tedizolid contributed to clinical remission, it may have also contributed to a multifocal
peripheral neuropathy. Its efficacy may also have been limited by continued immunosuppression, with evidence to suggest disease relapse or treatment failure after completion of combination
therapy.
Tedizolid can be considered, with caution, in combination
therapy for difficult cases of cutaneous NTM
infection.