Abstract | BACKGROUND AND AIMS: METHODS AND RESULTS: The study included 4748 nondiabetic participants from the Asymptomatic Polyvascular Abnormalities Community study. Carotid plaque stability was assessed using ultrasonography. The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Logistic regression was used to evaluate the association of the TyG index with carotid plaque stability by calculating odds ratio (OR) and 95% confidence interval (CI). Of the 4748 participants, 1192 (25.11%) participants had stable carotid plaque, and 1247 (26.26%) had unstable carotid plaque. The prevalence of unstable carotid plaque substantially increased with increasing TyG index tertile (P for trend <0.0001). In the fully adjusted model, the OR comparing participants in the highest versus the lowest tertile of the TyG index was 1.31 (95% CI, 1.09-1.57). The optimal cutoff point for the TyG index in case of unstable carotid plaque was 8.56. However, we did not observe a statistically significant association between the TyG index and stable carotid plaque. CONCLUSIONS: Elevated the TyG index was significantly associated with the prevalence of unstable carotid plaque in nondiabetic adults.
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Authors | Anxin Wang, Xue Tian, Yingting Zuo, Xiaoli Zhang, Shouling Wu, Xingquan Zhao |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 31
Issue 10
Pg. 2921-2928
(09 22 2021)
ISSN: 1590-3729 [Electronic] Netherlands |
PMID | 34353702
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Blood Glucose
- Triglycerides
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Topics |
- Adult
- Beijing
(epidemiology)
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Carotid Artery Diseases
(blood, diagnostic imaging, epidemiology)
- Cross-Sectional Studies
- Early Diagnosis
- Female
- Humans
- Male
- Middle Aged
- Plaque, Atherosclerotic
- Predictive Value of Tests
- Prevalence
- Prognosis
- Risk Assessment
- Risk Factors
- Rupture, Spontaneous
- Triglycerides
(blood)
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