Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma.

The level of mRNA expression and DNA structure of c-H-ras were examined in a transitional cell carcinoma (TCC) induced in C3H/He mice and Fisher rats by N-(4,5-nitro-2-furylthiazolyl)formamide (FANFT) and carried as serially transplanted tumors. Neither amplification nor gross rearrangements were detected by Southern analysis in the FANFT tumor. Increased expression of c-H-ras was detected by Northern and in situ hybridization in both the FANFT-induced mouse and rat TCC, as compared to normal urothelium. No expression of six other cellular oncogenes was detected in the tumor. It appears that the increase in H-ras expression in the FANFT tumor is specific to this oncogene and that increased expression of the H-ras gene may play a role in bladder carcinogenesis.
AuthorsI S Sawczuk, W Walsh, W King, C A Olsson, C Nguyen-Huu
JournalUrologia internationalis (Urol Int) Vol. 42 Issue 5 Pg. 321-5 ( 1987) ISSN: 0042-1138 [Print] SWITZERLAND
PMID3433577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • RNA, Messenger
  • Animals
  • Carcinoma, Transitional Cell (chemically induced, genetics)
  • Gene Expression Regulation
  • Mice
  • Mice, Inbred Strains
  • Neoplasm Transplantation
  • Oncogenes
  • RNA, Messenger (genetics)
  • Rats
  • Rats, Inbred F344
  • Urinary Bladder Neoplasms (chemically induced, genetics)

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