Abstract | BACKGROUND: PATIENTS AND METHODS: Prospective single-center observational study enrolling 268 adult patients with acute pancreatitis. Biomarkers including PSP were measured upon admission to the Emergency Department and severity scores as SOFA, PANC-3, and BISAP were computed. Patients were classified into mild-moderate (non-severe) and severe acute pancreatitis according to the Determinant-Based Classification Criteria. Area under the curve (AUC) and regression analysis were used to analyze the discrimination abilities and the association of biomarkers and scores with severity. RESULTS: Two hundred and thirty-five patients (87.7%) were classified as non-severe and 33 (12.3%) as severe acute pancreatitis. Median [IQR] PSP was increased in patients with severe acute pancreatitis (890 μg/L [559-1142] vs. 279 μg/L [141-496]; p < 0.001) and it was the best predictor (ROC AUC: 0.827). In multivariate analysis, PSP and urea were the only independent predictors for severe acute pancreatitis and a model combining them both (" biomarker model") showed an AUC of 0.841 for prediction of severe acute pancreatitis, higher than the other severity scores. CONCLUSIONS: PSP is a promising biomarker for predicting the severity of acute pancreatitis upon admission. A model combining PSP and urea might further constitute a potential tool for early risk stratification of this disease.
|
Authors | Carlos Rodríguez Rojas, Luis García de Guadiana-Romualdo, Senador Morán Sánchez, Josef Prazak, Virginia Algara Soriano, Yok-Ai Que, Romy Benninga, María Dolores Albaladejo-Otón |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 67
Issue 7
Pg. 3275-3283
(07 2022)
ISSN: 1573-2568 [Electronic] United States |
PMID | 34268662
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
|
Copyright | © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Chemical References |
- Biomarkers
- Lithostathine
- Urea
|
Topics |
- Acute Disease
- Adult
- Biomarkers
- Humans
- Lithostathine
- Pancreatitis
(diagnosis)
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- ROC Curve
- Risk Assessment
- Severity of Illness Index
- Urea
|