Abstract | OBJECTIVES: MATERIALS AND METHODS: The patients diagnosed with CCUP between 2009 and 2019 in our institution were analyzed retrospectively. The categorical variables were tested by χ2 test. Kaplan-Meier method was used for survival analysis. Log-rank test and Cox proportional hazards regression were performed with overall survival (OS) and disease-free survival (DFS) as the primary outcome variables. RESULTS: Of 139 patients, 64.7% (90/139) of them received radiotherapy. Of the 90 patients who underwent radiotherapy, 45.6% (41/90) received Involved Field radiotherapy and the rest 49 patients received Comprehensive radiotherapy. The median follow-up of 139 patients is 69 months. The 1-year, 3-year, and 5-year OS rates are 87%, 62%, and 39%, respectively, and the DFS rates are 73%, 45%, and 29%, respectively. Multivariate analysis of 139 patients with CCUP shows that differentiation grade, N stage, radiotherapy, and the length of the largest lymph node (DmaxLN) are the independent prognostic factors for both OS and DFS. Subgroup analysis of 90 patients who received radiotherapy shows that the Comprehensive radiotherapy group has a better OS (P < 0.001) and DFS (P < 0.001) compared with Involved Field radiotherapy. CONCLUSION:
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Authors | Ruidan Li, Kai Liao, Zhigong Wei, Zheran Liu, Yan He, Jingjing Wang, Ling He, Xiaoli Mu, Lianlian Yang, Yan Huang, Libang He, Xingchen Peng |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 148
Issue 6
Pg. 1437-1445
(Jun 2022)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 34245371
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Topics |
- Carcinoma, Squamous Cell
(pathology)
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
(radiotherapy)
- Neoplasm Staging
- Neoplasms, Unknown Primary
(pathology, radiotherapy)
- Prognosis
- Retrospective Studies
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