Renal and overall outcomes of double-positive (ANCA and anti-GBM antibodies) patients compared to ANCA-associated vasculitis patients with severe renal involvement: A multicenter retrospective study with systematic renal pathology analysis.

Abstract

OBJECTIVE:

Double-positive patients (DPPs), combining serum and/or histological findings for glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCAs), are rare and poorly described. This study aimed to compare characteristics between DPPs and ANCA-associated vasculitis (AAV) patients with severe renal involvement.

METHOD:

This retrospective multicentre study compared 33 DPPs and 45 AAV patients with severe renal involvement (serum creatinine > 300 μmol/L), all with biopsy-proven nephropathy.

RESULTS:

All DPPs (including 18% exhibiting negative serum anti-GBM antibodies) presented severe acute kidney failure with histological GBM involvement. Compared to AAV patients, they had higher serum creatinine (719 vs 501 μmol/L; p = 0.006) and a higher proportion of patients requiring initial renal replacement therapy (82% vs 36%; p < 0.001). Berden classification differed significantly (p = 0.003), with more crescentic glomerulonephritis and fewer sclerotic lesions in DPPs. One-year renal survival was significantly lower in DPPs than in AAV patients (27% vs 64%; p < 0.0002). With comparable proportions of ANCA subtypes (two-thirds with anti-myeloperoxidase autoantibodies), numbers of extrarenal manifestations (mostly pulmonary in two-thirds), remission-inducing immunosuppressants, and median follow-ups (3 years) between groups, relapse rates were similar: 9.1% of DPPs and 10% of AAV patients.

CONCLUSION:

Although DPPs have features of both kinds of vasculitis, the anti-GBM component is the dominant phenotype, with more severe renal presentation and prognosis compared to AAV patients with severe renal failure. Simultaneous testing of both antibodies and systematically performed renal biopsy should be recommended in all rapidly progressing glomerulonephritis patients to recognize this difficult-to-treat, rare disease.

• Authors: M Clerte, R Philip, C Levi, E Cornec-Le Gall, V Audard, A Huart, X Puéchal, M Touzot, N Rabot, É Thervet, A Aouba, A Karras
• Journal: Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 51 Issue 3 Pg. 205-213 (05 2022) ISSN: 1502-7732 [Electronic] England
• PMID: 34169779 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• antiglomerular basement membrane antibody
• Creatinine

Topics

• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (complications, therapy)
• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• Creatinine
• Female
• Glomerulonephritis (therapy)
• Humans
• Male
• Retrospective Studies