Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis.
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| Abstract |
Hyperuricemia contributes to chronic kidney disease development. However, it has been historically viewed with limited research interest. In this study, we mimicked the development of hyperuricemic nephropathy by using a potassium oxonate-induced hyperuricemia rat model. We found that administering vitamin C at 10 mg/kg/day effectively ameliorated hyperuricemic nephropathy. Compared to the control group, rats with hyperuricemia had significantly increased serum uric acid level, xanthine oxidase activity, and urine microalbumin level, by 5-fold, 1.5-fold, and 4-fold, respectively. At the same time, vitamin C supplementation reverted these values by 20% for serum uric acid level and xanthine oxidase activity and 50% for microalbumin level. Vitamin C also alleviated renal pathology and decreased the expression of pro-inflammatory and pro-fibrotic markers. A further mechanistic study suggested that vitamin C might attenuate hyperuricemic nephropathy in renal tubular epithelial cells induced by monosodium urate (MSU) crystal, at least in part, by directly inhibiting IL-6/JAK2/STAT3 signaling pathway. Meanwhile, in macrophages, vitamin C inhibited the expression of TGF-β, and reduced ROS level induced by MSU by about 35%. In short, our results suggest that vitamin C supplementation delay the progression of hyperuricemic nephropathy.
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| Authors | Hongling Li, Xuejiao Liu, Mee-Hyun Lee, Haitao Li |
| Journal | Journal of food science (J Food Sci) Vol. 86 Issue 7 Pg. 3265-3276 (Jul 2021) ISSN: 1750-3841 [Electronic] United States |
| PMID | 34160066 (Publication Type: Journal Article) |
| Copyright | © 2021 Institute of Food Technologists®. |
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