IL-1α and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy.

Abstract

Inflammation has been well-established as a hallmark of colorectal cancer (CRC). Interleukin-1 alpha (IL-1α) is one of the primary inflammatory mediators driving the pathogenesis of inflammation-associated CRC. This systematic review presents the roles of IL-1α in the pathogenesis of the disease. Bibliographic databases PubMed, Science Direct, Scopus and Web of Science were systematically searched for articles that addresses the relationship between IL-1α and colorectal cancer. We highlighted various mechanisms by which IL-1α promotes the pathogenesis of CRC including enhancement of angiogenesis, metastasis, resistance to therapy, and inhibition of tumour suppressive genes. We also discussed the potential mechanisms by which IL-1α expression is induced or secreted in various studies. Beyond these, the systematic review also highlights several potential therapeutic strategies which should be further explored in the future; to target IL-1α and/or its associated pathways; paving our way in finding effective treatments for CRC patients.

• Authors: Kim Jun Cheng, Elsa Haniffah Mejia Mohammed, Tak Loon Khong, Shamsul Mohd Zain, Surendran Thavagnanam, Zaridatul Aini Ibrahim
• Journal: Critical reviews in oncology/hematology (Crit Rev Oncol Hematol) Vol. 163 Pg. 103398 (Jul 2021) ISSN: 1879-0461 [Electronic] Netherlands
• PMID: 34147647 (Publication Type: Journal Article, Review, Systematic Review)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Interleukin-1alpha

Topics

• Colorectal Neoplasms (drug therapy, etiology)
• Humans
• Inflammation
• Interleukin-1alpha (genetics)
• Neovascularization, Pathologic (drug therapy)