Insulin resistance (IR) plays an important role in the development of
hypertension.
Triglyceride and
glucose index (TyG index), and
triglyceride to
high-density lipoprotein cholesterol ratio (TG/HDL-c) as effective IR surrogate indexes have been verified in numerous studies. Therefore, the authors conducted a large cross-sectional study to explore the association of TyG index and TG/HDL-c with
prehypertension and
hypertension in the same normoglycemic subjects from Tianjin, China. A total of 32 124 adults were eligible for this study. According to the level of blood pressure, the enrolled individuals were divided into three groups, which were normotension,
prehypertension, and
hypertension. In multiple logistic regression analysis, there was associated with
prehypertension and
hypertension when comparing the highest TyG index to the lowest TyG index and corresponding
ORs were 1.795 (1.638, 1.968) and 2.439 (2.205, 2.698), respectively. For TG/HDL-c, the corresponding
ORs were 1.514 (1.382, 1.658) and 1.934 (1.751, 2.137), respectively. Furthermore, when comparing the fourth quartile to the first quartile of TyG index and TG/HDL-c, respectively, both corresponding
ORs of
hypertension were higher than
prehypertension. Elevated TyG index and TG/HDL-c levels were associated with
prehypertension and
hypertension in normoglycemic individuals. Moreover, the TyG index was more significant than TG/HDL-c in distinguishing
hypertension. They have the potential to become cost-effective monitors in the hierarchical management of
prehypertension and
hypertension.