Analysis of the physiological and pathological factors of hospitalized patients taking warfarin and the correlation between drug interactions and warfarin efficacy.
Abstract | BACKGROUND: METHODS: We collected the medical records of 125 hospitalized patients who used warfarin from January 2018 to December 2019. Statistical analysis was performed on characteristics such as gender, age, treatment, diabetes, hyperlipidemia, hyperthyroidism, hypothyroidism, hepatitis, renal insufficiency, and nephritis; along with other pathological factors, such as aspirin, clopidogrel, spironolactone, amiodarone, amlodipine, trimetazidine, bisoprolol, isosorbide, atorvastatin, furosemide, digoxin, metoprolol, acarbose, levamlodipine, enoxaparin, moxifloxacin, levofloxacin, other drug interactions, and comorbidities. RESULTS: CONCLUSIONS:
Warfarin anticoagulation is affected by many factors. Therefore, medical personnel should pay close attention to the impact of these factors on the anticoagulant effect of warfarin. This study found that warfarin-related bleeding adverse drug reactions and anticoagulant effects have a significant association. Bleeding not only affected the total number of days hospitalized, but also extended the number of days of warfarin administration. However, in terms of patients' pathological states, international normalized ratio values combined with drugs used were not associated with disease and may only be a reference for bleeding risk.
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Authors | Li Zhang, Wen Chen, Danna Gan |
Journal | Annals of palliative medicine
(Ann Palliat Med)
Vol. 10
Issue 5
Pg. 5400-5406
(May 2021)
ISSN: 2224-5839 [Electronic] China |
PMID | 34107695
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Anticoagulants
(adverse effects)
- Drug Interactions
- Hemorrhage
- Humans
- International Normalized Ratio
- Warfarin
(adverse effects)
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