Abstract | BACKGROUND: OBJECTIVE: To determine whether circulating levels of microRNAs involved in HCM are associated with electrocardiographic and echocardiographic parameters. METHODS: This study enrolled 20 patients with familial HCM and 20 blood donors. Peripheral serum levels of miR-29a-3p, miR-199a-5p and miR-451a were assessed by quantitative real-time polymerase chain reaction and compared with levels in the control group. Whether circulating levels of miRNAs in HCM patients correlated with electrocardiographic and echocardiographic parameters was also assessed. RESULTS: Median circulating levels of miR-29a and miR-451a were significantly higher in HCM than the control group. Median miR-199a levels did not differ between groups. However, circulating levels of miR-199a negatively correlated with corrected QT duration (Bazett formula). Median miR-29a levels positively correlated with QRS duration. In addition, circulating levels of miR-29a correlated with maximal wall thickness, left ventricular mass index and left atrial volume index. CONCLUSIONS: The data suggested that serum levels of miR-29a and miR-451a were significantly increased in HCM patients. As the circulating level of miR-29a correlated with QRS duration, left ventricular hypertrophy and left atrial dilatation, the serum miR-199a level negatively correlated with corrected QT duration. These miRNAs may be seen as potential biomarkers for further research in HCM pathophysiology.
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Authors | Mehmet Rasih Sonsöz, Mustafa Yilmaz, Erdem Cevik, Huseyin Orta, Ahmet Kaya Bilge, Ali Elitok, Imran Onur, Evrim Komurcu-Bayrak |
Journal | Heart, lung & circulation
(Heart Lung Circ)
Vol. 31
Issue 2
Pg. 199-206
(Feb 2022)
ISSN: 1444-2892 [Electronic] Australia |
PMID | 34088630
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Circulating MicroRNA
- MIRN29a microRNA, human
- MIRN451 microRNA, human
- MicroRNAs
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Topics |
- Cardiomyopathy, Hypertrophic
(diagnosis, genetics)
- Circulating MicroRNA
(genetics)
- Dilatation
- Fibrosis
- Humans
- Hypertrophy, Left Ventricular
(diagnosis, genetics)
- MicroRNAs
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