Abstract | INTRODUCTION: METHODS: In this cross-sectional study, plasma XOR activity in 118 pre-dialysis CKD patients (age 68 [57-75] years; 64 males, 26 with diabetes mellitus [DM]) was determined using a newly established highly sensitive assay based on (13C2,15N2) xanthine and liquid chromatography/triple quadrupole mass spectrometry. RESULTS: Plasma glucose, hemoglobin A1c, and estimated glomerular filtration (eGFR) were significantly and positively correlated with plasma logarithmically transformed XOR (ln-XOR) activity. In multiple regression analyses, eGFR and hemoglobin A1c or plasma glucose were significantly, independently, and positively associated with plasma ln-XOR activity after adjusting for several confounders. Plasma XOR activity was significantly higher in CKD patients with (n = 26) than in those without (n = 92) DM (62.7 [32.3-122] vs. 25.7 [13.4-45.8] pmol/h/mL, p < 0.001). A total of 38 patients were taking uric acid-lowering drugs. Multiple regression analysis of CKD patients not administered uric acid-lowering drugs (n = 80) showed no significant association between eGFR and plasma ln-XOR activity. In contrast, association between glycemic control and plasma ln-XOR activity was significant even in CKD patients without uric acid-lowering drug treatment. CONCLUSIONS: These results indicate the importance of glycemic control in CKD patients in regard to decreased XOR, possibly leading to a decrease in CVD events.
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Authors | Shinya Nakatani, Eiji Ishimura, Takayo Murase, Takashi Nakamura, Ayumi Nakatani, Norikazu Toi, Kozo Nishide, Hideki Uedono, Akihiro Tsuda, Masafumi Kurajoh, Shinsuke Yamada, Katsuhito Mori, Masaaki Inaba, Masanori Emoto |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 46
Issue 4
Pg. 475-483
( 2021)
ISSN: 1423-0143 [Electronic] Switzerland |
PMID | 34082427
(Publication Type: Journal Article)
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Copyright | © 2021 The Author(s) Published by S. Karger AG, Basel. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- hemoglobin A1c protein, human
- Xanthine Dehydrogenase
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Topics |
- Aged
- Blood Glucose
(analysis)
- Cross-Sectional Studies
- Dialysis
- Female
- Glycated Hemoglobin
(analysis)
- Glycemic Control
- Humans
- Male
- Middle Aged
- Renal Insufficiency, Chronic
(blood)
- Xanthine Dehydrogenase
(blood)
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