Effectiveness of beinaglutide in a patient with late dumping syndrome after gastrectomy: A case report.

Abstract

RATIONALE:

Dumping syndrome is a frequent and potentially severe complication after gastric surgery. Beinaglutide, a recombinant human glucagon-like peptide-1 (GLP-1) which shares 100% homology with human GLP-1(7-36), has never been reported in the treatment of dumping syndrome before.

PATIENT CONCERNS:

The patient had undergone distal gastrectomy for gastric signet ring cell carcinoma 16 months ago. He presented with symptoms of paroxysmal palpitation, sweating, and dizziness for 4 months.

DIAGNOSIS:

He was diagnosed with late dumping syndrome.

INTERVENTIONS AND OUTCOMES:

The patient was treated with dietary changes and acarbose for 4 months before admitted to our hospital. The treatment with dietary changes and acarbose did not prevent postprandial hyperinsulinemia and hypoglycemia according to the 75 g oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) on admission.Therefore, the patient was treated with beinaglutide 0.1 mg before breakfast and lunch instead of acarbose. After the treatment of beinaglutide for 1 month, OGTT showed a reduction in postprandial hyperinsulinemia compared with before starting treatment, and the time in the range of 3.9 to 10 mmol/L became 100% in CGM. No side effect was observed in this patient during beinaglutide treatment.

LESSONS:

These findings suggest that beinaglutide may be effective for treating post-gastrectomy late dumping syndrome.

• Authors: Bo Ding, Yun Hu, Lu Yuan, Reng-Na Yan, Jian-Hua Ma
• Journal: Medicine (Medicine (Baltimore)) Vol. 100 Issue 21 Pg. e26086 (May 28 2021) ISSN: 1536-5964 [Electronic] United States
• PMID: 34032745 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Blood Glucose
• Peptide Fragments
• Recombinant Proteins
• glucagon-like peptide 1 (7-36)
• Glucagon-Like Peptide 1

Topics

• Blood Glucose (analysis)
• Carcinoma, Signet Ring Cell (surgery)
• Dumping Syndrome (blood, diagnosis, drug therapy, etiology)
• Gastrectomy (adverse effects)
• Glucagon-Like Peptide 1 (administration & dosage)
• Glucose Tolerance Test
• Humans
• Hyperinsulinism (blood, diagnosis, drug therapy, etiology)
• Hypoglycemia (blood, diagnosis, drug therapy, etiology)
• Male
• Middle Aged
• Peptide Fragments (administration & dosage)
• Postprandial Period
• Recombinant Proteins (administration & dosage)
• Stomach Neoplasms (surgery)
• Treatment Outcome