Emerging concepts in intestinal immune control of obesity-related metabolic disease.

Abstract

The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.

• Authors: Saad Khan, Helen Luck, Shawn Winer, Daniel A Winer
• Journal: Nature communications (Nat Commun) Vol. 12 Issue 1 Pg. 2598 (05 10 2021) ISSN: 2041-1723 [Electronic] England
• PMID: 33972511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cytokines

Topics

• Animals
• B-Lymphocytes (immunology)
• Cytokines (metabolism)
• Diet Therapy
• Gastrointestinal Microbiome (immunology)
• Humans
• Immune System (cytology, metabolism)
• Inflammation (immunology, metabolism)
• Insulin Resistance (immunology)
• Metabolic Diseases (immunology, metabolism, microbiology, therapy)
• Obesity (diet therapy, immunology, metabolism, therapy)
• T-Lymphocytes (immunology)