Abstract | BACKGROUND: METHODS: A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. The LVH and LVDD were assessed using two-dimensional echocardiography and tissue Doppler imaging. The associations of LVH/LVDD with clinical and laboratory variables were investigated using univariable and multivariable logistic regression analyses. RESULTS: In a multivariable analysis, the SUA level was an independent predictor of LVH (odds ratio [OR]: 1.40, 95% confidence interval [CI]: 1.31-1.50, P < 0.001). In addition, patient age, systolic blood pressure, intact parathyroid hormone levels, and left atrial volume index levels were independent predictors of LVH. The SUA level was also an independent predictor of LVDD (OR: 1.93, 95% CI: 1.53-2.43, P < 0.001). Furthermore, systolic blood pressure and left atrial volume index levels were an independent predictor of LVDD. Receiver-operating characteristic curve analysis showed that the best cutoff values of SUA levels for identifying LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively. CONCLUSION: The SUA level was an independent predictor of LVD and LVDD in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD.
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Authors | Il Young Kim, Byung Min Ye, Min Jeong Kim, Seo Rin Kim, Dong Won Lee, Hyo Jin Kim, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee |
Journal | PloS one
(PLoS One)
Vol. 16
Issue 5
Pg. e0251333
( 2021)
ISSN: 1932-6203 [Electronic] United States |
PMID | 33956863
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Biomarkers
(blood)
- Cross-Sectional Studies
- Echocardiography
- Female
- Humans
- Hypertrophy, Left Ventricular
(blood, etiology)
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Renal Insufficiency, Chronic
(blood, complications)
- Uric Acid
(blood)
- Ventricular Dysfunction, Left
(blood, etiology)
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