Diagnostic Utility of the Immunohistochemical Expression of Serine and Arginine Rich Splicing Factor 1 (SRSF1) in the Differential Diagnosis of Adult Gliomas.

Abstract

BACKGROUND:

The aim of this study was to investigate the immunohistochemical expression and distribution of serine and arginine rich splicing factor 1 (SRSF1) in a series of 102 cases of both diffuse and circumscribed adult gliomas to establish the potential diagnostic role of this protein in the differential diagnosis of brain tumors.

METHODS:

This retrospective immunohistochemical study included 42 glioblastoma cases, 21 oligodendrogliomas, 15 ependymomas, 15 pilocytic astrocytomas, 5 sub-ependymal giant cell astrocytoma and 4 pleomorphic xanthoastrocytomas.

RESULTS:

Most glioblastoma (81%), oligodendroglioma (71%), sub-ependymal giant cell astrocytoma (80%) and pleomorphic xanthoastrocytoma (75%) cases showed strong SRSF1 immunoexpression, while no detectable staining was found in the majority of ependymomas (87% of cases) and pilocytic astrocytomas (67% of cases).

CONCLUSIONS:

The immunohistochemical expression of SRSF1 may be a promising diagnostic marker of astrocytomas and oligodendrogliomas and its increased expression might allow for excluding entities that often enter into differential diagnosis, such as ependymomas and pilocytic astrocytomas.

• Authors: Giuseppe Broggi, Lucia Salvatorelli, Davide Barbagallo, Francesco Certo, Roberto Altieri, Elena Tirrò, Michele Massimino, Paolo Vigneri, Elia Guadagno, Grazia Maugeri, Velia D'Agata, Giuseppe Musumeci, Marco Ragusa, Giuseppe Maria Vincenzo Barbagallo, Daniela Russo, Rosario Caltabiano
• Journal: Cancers (Cancers (Basel)) Vol. 13 Issue 9 (Apr 26 2021) ISSN: 2072-6694 [Print] Switzerland
• PMID: 33925821 (Publication Type: Journal Article)