Cyclophosphamide in treatment of minimal change nephrotic syndrome.

Abstract

Nineteen children with the minimal change form of nephrotic syndrome were divided according to their pattern of response to prednisone: steroid-dependent and frequent relapsers. All patients received cyclophosphamide for 56 days in a single daily dose of 2.5 mg/kg (total 140 mg/kg), in order to prolong the length of remission. The percentage of patients who continued in remission at the end of the 1st, 2nd and 5th years was greater in the frequent-relapser group. This retrospective analysis confirms that the pattern of response to prednisone may be an important criterion for the selection of patients who will benefit from cyclophosphamide therapy.

• Authors: I Shohet, J Meyerovitch, M Aladjem, H Boichis
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 147 Issue 3 Pg. 239-41 (Apr 1988) ISSN: 0340-6199 [Print] Germany
• PMID: 3391218 (Publication Type: Journal Article)

Chemical References

• Cyclophosphamide
• Prednisone

Topics

• Adolescent
• Child
• Child, Preschool
• Cyclophosphamide (administration & dosage, adverse effects, therapeutic use)
• Drug Administration Schedule
• Drug Therapy, Combination
• Follow-Up Studies
• Humans
• Infant
• Nephrosis, Lipoid (drug therapy)
• Prednisone (administration & dosage, therapeutic use)
• Recurrence
• Retrospective Studies