Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.

Abstract

BACKGROUND/AIM:

The pathological significance of thrombospondin (TSP)-1 and -2 in bladder cancer (BC) is well-known whereas that of TSP-3, 4 and 5 remains unclear. Our aim is to clarify the pathological significance and prognostic roles of TSP-3 to 5 expression in BC patients.

PATIENTS AND METHODS:

TSP-3 to 5 expression, proliferation index (PI), apoptotic index (AI) and microvessel density (MVD) were evaluated in 206 BC patients by immunohistochemical techniques.

RESULTS:

TSP-5 expression was positively associated with grade, T stage, metastasis, and worse prognosis. PI in TSP-5-positive tissues was significantly higher compared to negative tissues. In contrast, AI in TSP-5-positive tissues was significantly lower compared to negative tissues. Expressions of TSP-3 and 4 were not associated with any clinicopathological features, survival, PI, or AI.

CONCLUSION:

TSP-5 plays important roles in malignant behavior via cell survival regulation whereas the pathological significance of TSP-3 and TSP-4 in BC might be minimal.

• Authors: Junki Harada, Yasuyoshi Miyata, Kyohei Araki, Tsuyoshi Matsuda, Yoshiaki Nagashima, Yuta Mukae, Kensuke Mitsunari, Tomohiro Matsuo, Kojiro Ohba, Yasushi Mochizuki, Hideki Sakai
• Journal: In vivo (Athens, Greece) (In Vivo) 2021 May-Jun Vol. 35 Issue 3 Pg. 1693-1701 ISSN: 1791-7549 [Electronic] Greece
• PMID: 33910854 (Publication Type: Journal Article)
• Copyright: Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Thrombospondin 1
• Thrombospondins

Topics

• Humans
• Neovascularization, Pathologic
• Prognosis
• Thrombospondin 1 (genetics)
• Thrombospondins (genetics)
• Urinary Bladder Neoplasms (genetics)