Experimental study on alleviating atherosclerosis through intervention of mitochondrial calcium transport and calcium-induced membrane permeability transition.

Abstract	To investigate the effort of mitochondrial calcium transport and calcium-induced membrane permeability transition in alleviating atherosclerosis. The experimental mice were divided into three groups: the control group (C57BL/6 mice with normal diet), the atherosclerosis group (apolipoprotein E-deficient (ApoE-/-) mice with high-fat diet) and the mitochondrial targeting agent group (ApoE-/- mouse with high-fat diet). The mean fluorescence intensity of Ca2+ in the atherosclerosis group is significantly higher than control group and mitochondrial targeting agent group. But the mean fluorescence intensity of Ca2+-ATPase is lower than other groups. The macrophage recruitment (F4/80 positive area) and the expression of tumor necrosis factor alpha, interleukin-6, pyrin domain containing protein 3, intercellular cell adhesion molecule-1, p38 mitogen-activated protein kinase and Jun kinase 1/2 phosphorylation in the atherosclerosis group are higher that other groups. Treatment with mitochondrial targeting agents reduced the levels of elevated cyt C and cleaved caspase-3 in atherosclerotic mice (p<0.05). Mitochondrial targeting agents interfere with mitochondrial calcium transport and calcium-induced membrane permeability transition, inhibit MAPK/JNK pathway activation, inhibit foam cell formation and alleviate the process of atherosclerosis.
Authors	Sisi Chen, Jianing Wang, Lei Zhang, Hao Xia
Journal	Journal of investigative medicine : the official publication of the American Federation for Clinical Research (J Investig Med) Vol. 69 Issue 6 Pg. 1156-1160 (08 2021) ISSN: 1708-8267 [Electronic] England
PMID	33906902 (Publication Type: Journal Article)
Copyright	© American Federation for Medical Research 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Chemical References	Calcium
Topics	Animals Atherosclerosis (drug therapy) Calcium (metabolism) Calcium Signaling Mice Mice, Inbred C57BL Mice, Knockout, ApoE Mitochondria (drug effects, metabolism) Permeability

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