The therapeutic potentials of apelin in obesity-associated diseases.

Abstract

Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has emerged as an adipokine more than fifteen years ago, integrating the field of inter-organs interactions. The apelin/APJ system plays important roles in several physiological functions both in rodent and humans such as fluid homeostasis, cardiovascular physiology, angiogenesis, energy metabolism. Thus the apelin/APJ system has generated great interest as a potential therapeutic target in different pathologies. The present review will consider the effects of apelin in metabolic diseases such as obesity and diabetes with a focus on diabetic cardiomyopathy among the complications associated with diabetes and APJ agonists or antagonists of interest in these diseases.

• Authors: I Castan-Laurell, C Dray, P Valet
• Journal: Molecular and cellular endocrinology (Mol Cell Endocrinol) Vol. 529 Pg. 111278 (06 01 2021) ISSN: 1872-8057 [Electronic] Ireland
• PMID: 33838166 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• APLN protein, human
• APLNR protein, human
• Anti-Obesity Agents
• Apelin
• Apelin Receptors
• Dipeptidyl-Peptidase IV Inhibitors
• Hypoglycemic Agents
• Metformin

Topics

• Animals
• Anti-Obesity Agents (therapeutic use)
• Apelin (genetics, metabolism)
• Apelin Receptors (genetics, metabolism, therapeutic use)
• Diabetes Mellitus, Type 2 (drug therapy, genetics, metabolism, pathology)
• Diabetic Cardiomyopathies (drug therapy, genetics, metabolism, pathology)
• Dipeptidyl-Peptidase IV Inhibitors (therapeutic use)
• Energy Metabolism (drug effects, genetics)
• Gene Expression Regulation
• Homeostasis (drug effects, genetics)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Metformin (therapeutic use)
• Obesity (drug therapy, genetics, metabolism, pathology)
• Signal Transduction