Abstract | PURPOSE: MATERIALS: A total of 102 patients undergoing FAC neoadjuvant chemotherapy were included in the study. SNP analysis was performed by RT-PCR from genomic DNA. Two SNPs were analyzed: ABCB1 rs1045642 (3435 C > T) and ABCG2 rs2231142 (421 G > T). RESULTS: In clinical response evaluation, significant associations were found between the ABCB1 C3435T genotype and breast cancer chemoresistant and chemosensitive patients (p < 0.05). In the early clinical response, patients with genotype C/C or C/T were more likely to be chemosensitive to neoadjuvant therapy than patients with genotype T/T (OR = 4.055; p = 0.0064). Association analysis between the ABCB1 gene polymorphism and the pathologic response to FAC chemotherapy showed that the C/C + C/T genotype was a protective factor against chemoresistance (OR = 3.714; p = 0.0104). Polymorphisms in ABCG2 indicated a lack of association with resistance to chemotherapy (p = 0.2586) evaluating the clinical or pathological response rate to FAC neoadjuvant chemotherapy. CONCLUSION: The early clinical response and its association with SNPs in the ABCB1 transporter are preserved until the pathological response to neoadjuvant chemotherapy; therefore, it could be used as a predictor of chemoresistance in locally advanced breast cancer patients of the Mexican population.
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Authors | Eneida Turiján-Espinoza, Víctor Manuel Ruíz-Rodríguez, Edith Elena Uresti-Rivera, Ernesto Martínez-Leija, José de Jesús Zermeño-Nava, Arturo Guel-Pañola, Silvia Romano-Moreno, Juan Manuel Vargas-Morales, Diana Patricia Portales-Pérez |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 87
Issue 6
Pg. 843-853
(06 2021)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 33740100
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABCB1 protein, human
- ABCG2 protein, human
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- Neoplasm Proteins
- Doxorubicin
- Cyclophosphamide
- Fluorouracil
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Topics |
- ATP Binding Cassette Transporter, Subfamily B
(genetics)
- ATP Binding Cassette Transporter, Subfamily G, Member 2
(genetics)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Breast Neoplasms
(drug therapy, genetics)
- Cyclophosphamide
(therapeutic use)
- Doxorubicin
(therapeutic use)
- Female
- Fluorouracil
(therapeutic use)
- Genotype
- Humans
- Middle Aged
- Neoadjuvant Therapy
(methods)
- Neoplasm Proteins
(genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Retrospective Studies
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