Abstract | BACKGROUND: AIM: METHODS: We performed a comprehensive literature search of major databases (from inception to November 2020) to identify studies which assess the incidence and risk of HCC following bariatric surgery. Pooled data were assessed using a random-effects model expressed in terms of odds ratio (OR), incidence rate ratio and 95% confidence interval (CI). RESULTS: Nine studies (two abstracts and seven full texts) were included for meta-analysis which involved 19 514 750 patients (18 423 546 controls and 1 091 204 bariatric patients). Pooled unadjusted odds ratio (OR) was 0.40 (95% CI: 0.28-0.57) which favoured bariatric surgery, though with high heterogeneity (I2 : 79%). Using an adjusted model derived from matched cohorts (five studies) yielded an OR of 0.63 (95% CI: 0.53-0.75) with moderate heterogeneity (I2 : 38%). The pooled rate/1000 person-years was 0.05 (95% CI: 0.02-0.07) in bariatric surgery patients and 0.34 (95% CI: 0.20-0.49) in the control group with an incidence rate ratio of 0.28 (95% CI: 0.18-0.42). CONCLUSION:
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Authors | Daryl Ramai, Jameel Singh, Janice Lester, Shahab R Khan, Saurabh Chandan, Nicola Tartaglia, Antonio Ambrosi, Gaetano Serviddio, Antonio Facciorusso |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 53
Issue 9
Pg. 977-984
(05 2021)
ISSN: 1365-2036 [Electronic] England |
PMID | 33721336
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | © 2021 John Wiley & Sons Ltd. |
Topics |
- Bariatric Surgery
- Carcinoma, Hepatocellular
(epidemiology, etiology, prevention & control)
- Humans
- Incidence
- Liver Neoplasms
(epidemiology, etiology, prevention & control)
- Weight Loss
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