Abstract | OBJECTIVE: METHODS: This was a 12-week, double-blind, randomized, placebo-controlled trial. A total of 148 patients with moderate AD participated in this study. Mini-Mental State Examination, Neuropsychiatric Inventory (NPI), Clinician's Interview-Based Impression of Change plus caregiver input, Gottfries-Bråne-Steen Scale, and Zarit Burden Interview were used as assessment scales. RESULTS: There were no significant differences in age, sex, or education between AChEIs alone and combination groups. The combination group showed significantly more improvement of NPI-disinhibition score (0.76±2.15) than the AChEIs alone group (-0.14±1.71) after 12 weeks. CONCLUSION: Our findings suggest that the combination therapy of memantine and AchEIs might be a beneficial option for reducing disinhibition symptoms of patients with moderate AD compared with AchEIs alone. We believe that clinicians need to consider additional memantine treatment when patients with moderate AD complain disinhibition symptom. A larger clinical trial is needed to further determine the efficacy and advantages of such combination therapy of memantine and AchEIs for treating BPSD of patients with moderate AD.
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Authors | HyunChul Youn, Kang Joon Lee, Shin-Gyeom Kim, Seong-Jin Cho, Woo Jung Kim, Won Joon Lee, Jae Yeon Hwang, Changsu Han, Cheolmin Shin, Han-Yong Jung |
Journal | Psychiatry investigation
(Psychiatry Investig)
Vol. 18
Issue 3
Pg. 233-240
(Mar 2021)
ISSN: 1738-3684 [Print] Korea (South) |
PMID | 33685036
(Publication Type: Journal Article)
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