[Analysis of the Different Therapeutic Effects in 21 Ph+ Acute Lymphoblastic Leukemia Children].

Abstract

OBJECTIVE:

To analyze the outcomes of the children suffered from philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) treated with tyrosine kinase inhibitor (TKI) plus chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT).

METHODS:

21 cases of firstly diagnosed Ph+ALL patients aged <12 year treated with Chinese Childhood Leukemia Group ALL 2008 (CCLG-ALL 2008) protocol form January 2008 and April 2015 were retrospectively analyzed．The patients were divided into two groups, one group was TKI+ chemotherapy group, the other group was allo-HSCT group.

RESULTS:

Among 21 patients, 17 were male and 4 were female with a median age of 8 years old (range, 4-12 years), the median follow-up time was 30 moths (range, 10-133 months). All the patients were treated with chemotherapy induced by the high-risk project of CCLG-ALL 2008. Among 14 patients treated with TKI plus chemotherapy, nine patients achieved complete remission. During 3 months after treatment, patients without complete molecular response or with the second complete remission and intensity desire of transplantation were treated with allo-HSCT, among 9 patients with allo-HSCT, six patients achieved long term survival.

CONCLUSION:

At TKI era, TKI combined with strong chemotherapy can make Ph+ ALL children achieve 5 years event-free survival as campared those treated with allo-HSCT. However, for the patients without complete molecular response persistently and relapsed they can still benefit from allo-HSCT.

• Authors: Shu-Chun Wang, Ye Guo, Xiao-Juan Chen, Xiao-Ming Liu, Min Ruan, Wen-Yu Yang, Li Zhang, Yao Zou, Yu-Mei Chen, Xiao-Fan Zhu
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 29 Issue 1 Pg. 38-42 (Feb 2021) ISSN: 1009-2137 [Print] China
• PMID: 33554794 (Publication Type: Journal Article)

Chemical References

• Protein Kinase Inhibitors

Topics

• Aged
• Child
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Infant
• Male
• Philadelphia Chromosome
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)
• Protein Kinase Inhibitors
• Retrospective Studies