Pancreatic cancer, one of the most malignant gastrointestinal
tumors, is prone to liver
metastasis. However, due to the lack of appropriate and comprehensive diagnostic methods, it is difficult to accurately predict the survival outcomes. Therefore, there is a need to identify effective
biomarkers, such as
UDP-GlcNAc: βGal β-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3), that predict the survival outcome of patients with
pancreatic cancer. In the present study, based on data from 171 cases of
pancreatic cancer obtained from The
Cancer Genome Atlas portal, the differential expression of mRNAs was screened by comparing cancerous tissues with adjacent tissues. Univariate Cox regression analysis demonstrated that B3GNT3 had prognostic capability and could be an independent prognostic factor for pancreatic
adenocarcinoma (PAAD). Using the
Tumor Immune Estimation Resource tool and
Tumor-Immune System Interaction Database, a potential relationship between B3GNT3 expression and immune cell infiltration was identified in
pancreatic carcinoma. Furthermore, 177 samples of
pancreatic carcinoma were collected and the association of CD68 expression with B3GNT3 was assessed by immunohistochemical staining. B3GNT3 expression was associated with clinical outcomes in
pancreatic carcinoma and related to infiltrating levels of immune cells, which indicated that B3GNT3 could be used as an
immunotherapy target for PAAD.