Smart Assembled Human Serum Albumin Nanocarrier Enhanced Breast Cancer Treatment and Antitumor Immunity by Chemo- photothermal Therapy.

Abstract

High invasion and metastasis are the major obstacles to successful breast cancertherapy. Indocyanine green (ICG), a photosensitizer for photothermal therapy (PTT), shows potent anticancer efficacy when combined with the chemotherapeutic drug doxorubicin (DOX). Human serum albumin (HSA), a biocompatible carrier material, has been successfully used for the delivery of paclitaxel (Abraxane). In addition, there are ICG functional binding regions in HSA. Thus, a smart assembled nanoplatform (DI@HSA NPs) was constructed to achieve the synergistic effects of chemo- photothermal therapy against breast cancer. Compared to free ICG and free DOX, DI@HSA NPs showed satisfactory stability and exhibited an enhanced tumor targeting capacity. The mild hyperthermia generated by DI@HSA NPs can not only cause tumor photothermal ablation and promote the uptake of DI@HSA NPs by 4T1 cells, but also protect the healthy tissues nearby the tumor from overheating injury. More importantly, DI@HSA NPs greatly amplified the infiltration of CD4+ T cells and CD8+ T cells, resulting in inhibited tumor growth and metastasis. DI@HSA NPs, as a simple biocompatible nanoagent, showed excellent inhibition of breast cancer growth and metastasis by chemo-photothermal therapy, providing a potential strategy for the future therapy of breast cancer.

• Authors: Huisong Ma, Xiqin Yang, Jia Ke, Cheng Wang, Lijun Peng, Fuqiang Hu, Hong Yuan
• Journal: ACS biomaterials science & engineering (ACS Biomater Sci Eng) Vol. 6 Issue 5 Pg. 3217-3229 (05 11 2020) ISSN: 2373-9878 [Electronic] United States
• PMID: 33463256 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Serum Albumin, Human

Topics

• Breast Neoplasms (drug therapy)
• CD8-Positive T-Lymphocytes
• Humans
• Hyperthermia, Induced
• Photothermal Therapy
• Serum Albumin, Human