Abstract | ABSTRACT: Abnormal change on the tongue is a potential complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The exact pathogenesis remains unclear and several risk factors include chemoradiotherapy, infection, graft-versus-host disease, disease relapse, and secondary malignancy. Our case described a 42-year-old woman with B-cell acute lymphoblastic leukemia treated by allo-HSCT 2 months later followed by a rare and atypical tongue neoplasia without oral pain, dysphagia, and dysgeusia. The biopsy was operated which showed granulation tissue with no evidence on typical graft-versus-host disease or malignancy, and no specific infection had been identified. Cyclosporine and mycophenolate mofetil, which were used for immunosuppression after allo-HSCT accompanying with the rapid growth of the tongue neoplasia, was then replaced by sirolimus. One month later, the patient underwent a complete remission unexpectedly.
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Authors | Xi Qiu, Teng Yu, Yang Xu |
Journal | The Journal of craniofacial surgery
(J Craniofac Surg)
2021 Jul-Aug 01
Vol. 32
Issue 5
Pg. e452-e454
ISSN: 1536-3732 [Electronic] United States |
PMID | 33405438
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2020 by Mutaz B. Habal, MD. |
Topics |
- Adult
- B-Lymphocytes
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(therapy)
- Tongue
- Transplantation, Homologous
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