Prognostic value of RASD1 transcript levels in adult Philadelphia-negative B-cell acute lymphoblastic leukemia.

Abstract

OBJECTIVES:

Ras-related dexamethasone-induced 1 (RASD1) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, RASD1, as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL.

METHODS:

The expression of RASD1 was detected with RT-qPCR in 92 adults with de novo Ph-negative B-ALL and 40 healthy controls. The correlation between RASD1 transcript levels and relapse was assessed.

RESULTS:

RASD1 transcript levels in patients with Ph-negative B-ALL (median 81.76%, range 0.22%-1824.52%) were significantly higher than those in healthy controls (7.59%, 0.46%-38.66%; P<0.0001). Patients with low RASD1 transcript levels had a lower 5-year relapse-free survival (RFS, 47.5% [32.9%, 62.1%] vs. 63.1% [49.0%, 77.2%]; P = 0.012) and a higher 5-year cumulative incidence of relapse (CIR, 52.0% [37.4%, 66.6%] vs. 36.2% [22.2%, 50.2%]; P = 0.013) especially in patients receiving chemotherapy only. Multivariate analysis showed that a low RASD1 transcript level was an independent risk factor for RFS (HR = 2.938 [1.427, 6.047], P = 0.003) and CIR (HR = 3.367 [1.668, 6.796], P = 0.001) in patients with Ph-negative B-ALL.

CONCLUSIONS:

RASD1 transcript levels were significantly higher in patients with Ph-negative B-ALL and a low RASD1 transcript level was independently correlated with increased relapse risk.

• Authors: Run-Qing Lu, Li-Xin Wu, Jing Zhang, Ya-Zhen Qin, Yan-Rong Liu, Yue-Yun Lai, Hao Jiang, Ying-Jun Chang, Guo-Rui Ruan, Xiao-Jun Huang
• Journal: Hematology (Amsterdam, Netherlands) (Hematology) Vol. 26 Issue 1 Pg. 9-15 (Dec 2021) ISSN: 1607-8454 [Electronic] England
• PMID: 33357137 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• RASD1 protein, human
• ras Proteins

Topics

• Adolescent
• Adult
• Aged
• B-Lymphocytes (pathology)
• Biomarkers, Tumor (genetics)
• Female
• Gene Expression Regulation, Leukemic
• Humans
• Male
• Middle Aged
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis, genetics, pathology)
• Prognosis
• Up-Regulation
• Young Adult
• ras Proteins (genetics)