Abstract | PURPOSE: To evaluate the course of prenatally diagnosed and early-enrolled congenital solitary functioning kidney patients followed until adulthood and to identify risk factors for kidney injury. MATERIALS AND METHODS: Among all congenital solitary functioning kidney patients followed (1993-2018), we recalled 56 patients with prenatal diagnosis and congenital solitary functioning kidney confirmation at 1-3 months of life reaching at least 18 years of age. Serum uric acid, heavy smoking (≥25 cigarettes/day) and overweight/ obesity were clustered as modifiable risk factors. Kidney injury was defined by estimated glomerular filtration rate <90 ml/minute/1.73 m2 and/or 24-hour ambulatory blood pressure monitoring confirmed hypertension and/or proteinuria. Modifiable risk factors and congenital anomalies of the kidney and urinary tract ( CAKUT) of congenital solitary functioning kidney were evaluated as risk factors for kidney injury. RESULTS: The mean followup period was 21.1 years (range 18-33 years). Mild kidney injury was found in 15 out of 56 patients (26.8%). The mean age at proteinuria, reduced estimated glomerular filtration rate and hypertension onset was 19.7 years (1.2 SDS), 20.7 years (2.7 SDS), and 22 years (5.6 SDS), respectively. Patients with CAKUT of congenital solitary functioning kidney and with both CAKUT of congenital solitary functioning kidney and modifiable risk factors presented survival free from kidney injury of 0% at 22.2 and 24.2 years of age, respectively. Patients with modifiable risk factors presented 42.4% of survival at 30 years. Patients without CAKUT of congenital solitary functioning kidney nor modifiable risk factors presented 100% of survival at 30 years of age (p=0.002). The presence of CAKUT of congenital solitary functioning kidney was the only significant risk factor (HR 4.9; 95% CI 1.8-14.2; p=0.003). CONCLUSIONS:
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Authors | Pierluigi Marzuillo, Stefano Guarino, Anna Di Sessa, Pier Francesco Rambaldi, Alfonso Reginelli, Giovanna Vacca, Salvatore Cappabianca, Daniela Capalbo, Tiziana Esposito, Carla De Luca Picione, Maria Rosaria Arienzo, Grazia Cirillo, Angela La Manna, Emanuele Miraglia Del Giudice, Cesare Polito |
Journal | The Journal of urology
(J Urol)
Vol. 205
Issue 5
Pg. 1466-1475
(May 2021)
ISSN: 1527-3792 [Electronic] United States |
PMID | 33350324
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Infant
- Infant, Newborn
- Male
- Prenatal Diagnosis
- Solitary Kidney
(complications, congenital, diagnosis, physiopathology)
- Young Adult
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