Safety and feasibility of low-dose ticagrelor in patients with ST-segment elevation myocardial infarction.

Abstract

BACKGROUND:

Previous studies have confirmed the safety and feasibility of half-dose ticagrelor in Chinese patients with acute coronary syndrome, but currently there is no plan for the use of ticagrelor for Chinese ST-segment elevation myocardial infarction (STEMI) patients.

HYPOTHESIS:

It is safe and feasible of low-dose ticagrelor in patients with STEMI.

METHODS:

The STEMI patients who were undergoing emergency intervention and taking ticagrelor were enrolled. Patients whose level of platelet aggregation rate (PAR) less than 30% after 7-day treatment with standard-dose ticagrelor were randomly divided into low-dose group (LD group, 45 mg twice daily) and standard-dose group (SD group, 90 mg twice daily). The changes of levels of platelet parameters were compared between the two groups. The incidence of major adverse cardiac events (MACE), bleeding events were compared between the two groups within 6 months of follow-up.

RESULTS:

The levels of PAR in the SD group decreased compared with baseline, and was lower than those of LD group at the same time point. The levels of platelet distribution width in both groups decreased from the baseline values (all p < .05) at 1, 3, and 6 months after grouping treatment, but there was no significant difference between the two groups. The incidence of MACE was similar between the two groups of patients. There were decreasing trends in the incidences of minimal bleeding event, minor bleeding event, dyspnea, and gout in the LD group.

CONCLUSION:

It is safe and feasible of low-dose ticagrelor for patients with STEMI based on the monitoring of PAR.

• Authors: Yanbo Wang, Yunfa Jiang, Wei Zhi, Yang Fu, Qing Wang, Jianli Zhou, Shaochen Zheng, Guozhen Hao
• Journal: Clinical cardiology (Clin Cardiol) Vol. 44 Issue 1 Pg. 123-128 (Jan 2021) ISSN: 1932-8737 [Electronic] United States
• PMID: 33320381 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2020 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.

Chemical References

• Platelet Aggregation Inhibitors
• Ticagrelor

Topics

• Adult
• Aged
• Dose-Response Relationship, Drug
• Feasibility Studies
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (administration & dosage)
• Prospective Studies
• ST Elevation Myocardial Infarction (drug therapy)
• Ticagrelor (administration & dosage)
• Young Adult