Advances in Receptor-Targeted Radiolabeled Peptides for Melanoma Imaging and Therapy.

Abstract

Melanocortin-1 receptor (MC1R) and very late antigen-4 (VLA-4, integrin α4β1) are 2 attractive molecular targets for developing peptide radiopharmaceuticals for melanoma imaging and therapy. MC1R- and VLA-4-targeting peptides and peptide-conjugated Cornell prime dots (C' dots) can serve as delivery vehicles to target both diagnostic and therapeutic radionuclides to melanoma cells for imaging and therapy. This review highlights the advances of MC1R- and VLA-4-targeted radiolabeled peptides and peptide-conjugated C' dots for melanoma imaging and therapy. The promising preclinical and clinical results of these new peptide radiopharmaceuticals present an optimistic outlook for clinical translation into receptor-targeting melanoma imaging and radionuclide therapy in the future.

• Authors: Yubin Miao, Thomas P Quinn
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 62 Issue 3 Pg. 313-318 (03 2021) ISSN: 1535-5667 [Electronic] United States
• PMID: 33277401 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: © 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Chemical References

• Receptors, Peptide

Topics

• Animals
• Humans
• Isotope Labeling
• Melanoma (diagnostic imaging, metabolism, radiotherapy)
• Molecular Imaging (methods)
• Molecular Targeted Therapy
• Receptors, Peptide (metabolism)