Abstract | INTRODUCTION: METHODS: In the present study, we investigated the effect of dietary supplementation of γ-GC on oxidative stress and Aβ pathology in the brains of APP/PS1 mice. The APP/PS1 mice were fed γ-GC from 3 months of age with biomarkers of apoptosis and cell death, oxidative stress, neuroinflammation and Aβ load being assessed at 6 months of age. RESULTS: CONCLUSION: Our data collectively suggested that supplementation with γ-GC may represent a novel strategy for the treatment and/or prevention of cognitive impairment and neurodegeneration.
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Authors | Yue Liu, Zheng Chen, Ben Li, Hua Yao, Martin Zarka, Jeffrey Welch, Perminder Sachdev, Wallace Bridge, Nady Braidy |
Journal | Neurochemistry international
(Neurochem Int)
Vol. 144
Pg. 104931
(03 2021)
ISSN: 1872-9754 [Electronic] England |
PMID | 33276023
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Amyloid
- Dipeptides
- gamma-glutamylcysteine
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Topics |
- Alzheimer Disease
(drug therapy, metabolism, pathology)
- Amyloid
(antagonists & inhibitors, metabolism)
- Animals
- Dietary Supplements
- Dipeptides
(administration & dosage)
- Disease Models, Animal
- Encephalitis
(drug therapy, metabolism, pathology)
- Male
- Mice
- Mice, Transgenic
- Oxidative Stress
(drug effects, physiology)
- Spatial Memory
(drug effects, physiology)
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