Abstract | PURPOSE: METHODS: RESULTS: ALT and AST concentrations in the serum were reduced and TNF-α, IL-1β, and IL-6 expressions were decreased by PDRN injection in CCl4-evoked ALI mice. PDRN injection suppressed Bax versus Bcl-2 ratio and reduced the percentage of TUNE-positive cells in CCl4-evoked ALI mice. PDRN injection overexpressed adenosine A2A receptor in CCl4-evoked ALI mice. CONCLUSION: The therapeutic efficacy of PDRN also can be expected for CCl4-evoked acute urogenital injury in addition to ALI. The current research suggests that PDRN may be used for the therapeutic agent of CCl4-evoked ALI.
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Authors | Seunghwan Lee, Kyu Yeoun Won, Sunhyung Joo |
Journal | International neurourology journal
(Int Neurourol J)
Vol. 24
Issue Suppl 2
Pg. 88-95
(Nov 2020)
ISSN: 2093-4777 [Print] Korea (South) |
PMID | 33271005
(Publication Type: Journal Article)
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