Abstract |
Several reports have suggested that photobiomodulation, owing to its analgesic, anti-inflammatory, and healing effects, may be an effective therapeutic option for local effects of snakebites when the availability and accessibility of conventional serum therapy are inefficient and far from medical care centers. Although there have been studies that demonstrate the application of photobiomodulation in the treatment of local adverse events due to snakebites from snakes of the genus Bothrops, its role in the activation of leukocytes, particularly macrophages, has not been evaluated. Here, we assessed the effect of light-emitting diode (LED) treatment on macrophage activation induced by B. jararacussu venom (BjV). LED treatment caused an increase in the viability of macrophages incubated with BjV. This treatment reduced reactive oxygen species (ROS) and nitric oxide (NO) production by macrophages after incubation with BjV. However, LED treatment did not interfere with IL-1β and IL-10 production by macrophages after incubation with BjV. In conclusion, this study showed that LED treatment has the potential to be used in combination with conventional serum therapy to prevent or minimize the progression of local to severe symptoms after Bothrops envenomation.
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Authors | Valdison P Reis, Cristina M A Rego, Sulamita S Setúbal, Maria Naiara M Tavares, Charles N Boeno, Alex A Ferreira E Ferreira, Mauro V Paloschi, Andreimar M Soares, Stella R Zamuner, Juliana P Zuliani |
Journal | Chemico-biological interactions
(Chem Biol Interact)
Vol. 333
Pg. 109347
(Jan 05 2021)
ISSN: 1872-7786 [Electronic] Ireland |
PMID | 33259806
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
- Crotalid Venoms
- Interleukin-1beta
- Reactive Oxygen Species
- Superoxides
- Interleukin-10
- Nitric Oxide
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Topics |
- Animals
- Bothrops
- Cell Survival
(drug effects)
- Crotalid Venoms
(toxicity)
- Interleukin-10
(metabolism)
- Interleukin-1beta
(metabolism)
- Intracellular Space
(drug effects, metabolism, radiation effects)
- Low-Level Light Therapy
(instrumentation)
- Macrophages
(immunology, radiation effects)
- Male
- Mice
- Nitric Oxide
(biosynthesis)
- Reactive Oxygen Species
(metabolism)
- Semiconductors
- Snake Bites
(immunology, metabolism, pathology, radiotherapy)
- Superoxides
(metabolism)
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