Abstract | OBJECTIVE: METHODS: Sixty newly diagnosed AGHD patients were included in our study, 24 of whom were evaluated after at least one year of GH treatment. Anthropometric parameters, glucolipid metabolism and the adipokine adipsin were measured. Visceral adipose tissue (VAT) and body composition were evaluated using a dual-energy X-ray-absorptiometry (DXA) scanner. RESULTS: At baseline, the higher VAT group had worse glucolipid metabolism parameters. Basal GH was negatively associated with VAT (r=-0.277, p = 0.045), while minimal correlations were found with fat mass depots, such as limbs and trunk fat (all p > 0.05). Adipsin was correlated with total body fat (r = 0.543, p < 0.001), VAT (r = 0.563, p < 0.001) and insulin resistance (r = 0.353, p = 0.006). The effect of GH administration on fat distribution was mainly reflected in the reduction in VAT. Partial improvements were found in lipid profiles, including increased high-density lipoprotein (HDL) and decreases in triglycerides (TGs) and lipoprotein(a), while glucose metabolism showed little change. The adipsin level also decreased significantly. The best predictors of VAT at baseline were trunk fat and IGF-I, and after treatment, VAT was predicted by decreased adipsin and an increase in lean mass. CONCLUSIONS: (1) VAT is an important metabolic risk factor for AGHD patients. (2) GH treatment decreased body fat predominantly in the visceral and central fat depots. (3) The lipid profiles partially improved after treatment, while glucose metabolism showed little change.
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Authors | Yunting Wang, Xiaoya Zheng, Xin Xie, Wenjie Qian, Ziyu Ren, Yue Chen, Xun Wu, Kun Liao, Wei Ren |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 132
Pg. 110875
(Dec 2020)
ISSN: 1950-6007 [Electronic] France |
PMID | 33254428
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved. |
Chemical References |
- Biomarkers
- Human Growth Hormone
- CFD protein, human
- Complement Factor D
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Body Fat Distribution
(trends)
- Cohort Studies
- Complement Factor D
(metabolism)
- Female
- Human Growth Hormone
(administration & dosage, blood, deficiency)
- Humans
- Intra-Abdominal Fat
(drug effects, metabolism)
- Male
- Middle Aged
- Risk Factors
- Treatment Outcome
- Young Adult
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