Abstract | OBJECTIVES: Cytomegalovirus (CMV)-related encephalitis is a rare but potentially life-threatening complication of CMV infection in immunocompromised patients. The high mortality rate is associated with deficient immune system reconstitution after hematopoietic stem cell transplant (HSCT) and poor bioavailability of antiviral drugs in cerebrospinal fluid (CSF). CMV-related central nervous system ( CNS) infection may occur with aspecific symptoms, without evidence of either blood viral load or magnetic resonance imaging (MRI) signs of encephalitis. METHODS: RESULTS: After three weeks, the CSF viral load dropped significantly and was undetectable within three more weeks. In the meantime, the renal impairment resolved, and there was a complete bone marrow recovery. CONCLUSION: We suggest that this patient succeeded in achieving CMV CSF clearance with high dose of CMV-hyperimmune globulin, given alone, because of the ability of immunoglobulins to penetrate the blood-brain barrier (BBB).
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Authors | Natalia Maximova, Annalisa Marcuzzi, Irene Del Rizzo, Davide Zanon, Alessandra Maestro, Egidio Barbi, Roberto Sala |
Journal | Clinical & translational immunology
(Clin Transl Immunology)
Vol. 9
Issue 11
Pg. e1201
( 2020)
ISSN: 2050-0068 [Print] Australia |
PMID | 33235734
(Publication Type: Case Reports)
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Copyright | © 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc. |