Immune Reconstitution Inflammatory Syndrome

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207 relevant articles (5 outcomes, 6 trials/studies) found for this Disease

Description: Exuberant inflammatory response towards previously undiagnosed or incubating opportunistic pathogens. It is frequently seen in AIDS patients following HAART.

Also Known As:

Immune Reconstitution Syndrome; Disease, Immune Reconstitution; Immune Reconstitution Syndromes; Reconstitution Disease, Immune; Reconstitution Syndrome, Immune; Reconstitution Syndromes, Immune; Restoration Syndrome, Immune; Syndrome, Immune Reconstitution; Syndrome, Immune Restoration; Syndromes, Immune Reconstitution; Immune Reconstitution Disease; Immune Restoration Syndrome

Relationship Network

Disease Context: Research Results

Immune System Diseases: 1319

Immune Reconstitution Inflammatory Syndrome: 207

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS)
2.	HIV Infections (HIV Infection)
3.	Progressive Multifocal Leukoencephalopathy
4.	Meningoencephalitis
5.	Infection

Experts

1.	Nacher, Mathieu: 3 articles (11/2007 - 03/2006)
2.	El Guedj, Myriam: 3 articles (11/2007 - 03/2006)
3.	Clyti, Emmanuel: 3 articles (11/2007 - 03/2006)
4.	Couppié, Pierre: 3 articles (11/2007 - 03/2006)
5.	Hamill, Richard J: 3 articles (04/2005 - 05/2002)
6.	Visnegarwala, Fehmida: 3 articles (04/2005 - 05/2002)
7.	Shelburne, Samuel A: 3 articles (04/2005 - 05/2002)
8.	Mahamat, Aba: 2 articles (11/2007 - 10/2007)
9.	Carme, Bernard: 2 articles (11/2007 - 10/2007)
10.	Aznar, Christine: 2 articles (11/2007 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Immune Reconstitution Inflammatory Syndrome:

1.	Biological Markers (Surrogate Marker)IBA 11/10/2009 - "Despite the association of contrast enhancement and immune reconstitution inflammatory syndrome with JCV-specific CTL, these cannot be considered as surrogate markers for the prognostic value of the CTL. " 02/15/2004 - "Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)-infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection. " Order ALL the reference details at left...
2.	Azithromycin (Zithromax)FDA LinkGeneric 02/01/2002 - "Azithromycin appeared to be protective against disseminated MAC in patients who were either unresponsive or nonadherent to HAART, but it did not prevent the development of immune reconstitution disease due to MAC." Order ALL the reference details at left...
3.	maraviroc FDA Link 11/27/2009 - "Is maraviroc beneficial in paradoxical progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome management?" Order ALL the reference details at left...
4.	liposomal amphotericin B FDA Link 08/01/2008 - "Liposomal amphotericin B for a case of intractable cryptococcal meningoencephalitis and immune reconstitution syndrome." 08/01/2008 - "We examined the efficacy of liposomal amphotericin B (L-AMB) for intractable cryptococcal meningoencephalitis in a patient with acquired immunodeficiency syndrome (AIDS) and the presence of immune reconstitution syndrome (IRS) caused by the treatment. " Order ALL the reference details at left...
5.	Carbon MonoxideIBA 03/01/2007 - "Immune reconstitution inflammatory syndrome in an HIV/TB co-infected patient four years after starting antiretroviral therapy." 09/01/2008 - "A prospective and multi-centre study has allowed us to analyse antibody responses and Mycobacterium tuberculosis clinical isolate genotypes on 24 consecutive HIV-TB co-infected patients treated with Highly Active Antiretroviral Therapy (HAART) who either went on to develop a TB Immune Restoration Syndrome (TB-IRS), or not. " 05/01/2001 - "Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. " 10/01/2009 - "Tegumentary leishmaniasis as the cause of immune reconstitution inflammatory syndrome in a patient co-infected with human immunodeficiency virus and Leishmania guyanensis." 01/01/2009 - "Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium tuberculosis (M.tb), co-morbid illnesses, poor adherence to therapy, tuberculosis associated-immune reconstitution inflammatory syndrome (TB-IRIS) and subtherapeutic antitubercular drug levels. " Order ALL the reference details at left...
6.	AntigensIBA 05/01/2008 - "The development and severity of the immune reconstitution inflammatory syndrome (IRIS) was dependent on the antigen load at the time of immunosuppression and subsequent bacillary replication during corticosteroid-induced immunosuppression. " 01/01/2005 - "This paradoxical worsening is known as the immune reconstitution inflammatory syndrome (IRIS) and it results from reconstitution of the immune system's ability to recognize pathogens/antigens in patients with prior OIs and low CD4+ T-cell counts. " 05/01/2008 - "Immune reconstitution inflammatory syndrome (IRIS) is particularly observed after the start of therapy for pathogenic antigens in patients infected with human immunodeficiency virus (HIV) and receiving highly active antiretroviral therapy (HAART). " 01/01/2007 - "The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients initiating antiretroviral therapy (ART) results from restored immunity to specific infectious or non-infectious antigens. " 08/01/2006 - "Immune reconstitution syndrome (IRS) is an immune response to an occult opportunistic pathogen or tumor antigen, usually occurs after antiretroviral treatment. " Order ALL the reference details at left...
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/01/2009 - "In addition to HIV-infected patients, immune reconstitution inflammatory syndrome has also been observed in solid organ transplant recipients, women during the postpartum period, neutropenic patients, and tumor necrosis factor antagonist recipients. " 12/01/2007 - "This case of de novo tuberculosis during anti-tumor necrosis factor alpha treatment illustrates the uncharacteristic presentation of the disease and the elusiveness of the diagnosis, as well as the fact that discontinuation of anti-tumor necrosis factor alpha treatment can be accompanied by an immune reconstitution syndrome similar to that observed in human immunodeficiency virus-infected individuals with tuberculosis." 07/01/2009 - "Immune reconstitution inflammatory syndrome after cessation of the tumor necrosis factor alpha blocker adalimumab in cryptococcal pneumonia." Order ALL the reference details at left...
8.	Tuberculin (PPD)IBA 09/15/2009 - "Tuberculosis (TB)-associated immune restoration syndrome (IRS) is a frequent event (10 to 30%) in HIV-1-infected patients receiving antiretroviral treatment and is associated with an increased number of IFN-gamma-producing tuberculin-specific cells. " 09/15/2009 - "Tuberculosis-associated immune restoration syndrome in HIV-1-infected patients involves tuberculin-specific CD4 Th1 cells and KIR-negative gammadelta T cells." 11/15/2008 - "RATIONALE: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) induced by combination antiretroviral therapy (cART) has been attributed to dysregulated expansion of tuberculin PPD-specific IFN-gamma-secreting CD4(+) T cells. " 01/09/2006 - "Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients." Order ALL the reference details at left...
9.	SteroidsIBA 04/15/2004 - "Specific antimicrobial therapy, nonsteroidal anti-inflammatory drugs, and/or steroids for managing immune reconstitution syndrome should be considered." 05/01/2009 - "He had taken short-terms steroids to treat a drug allergy and immune reconstitution syndrome. " 06/01/2006 - "Most of the evidence supporting the use of corticosteroids (steroids) for immune reconstitution syndrome (IRS) comes from case reports or retrospective series and is of low quality. " Order ALL the reference details at left...
10.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/01/2006 - "Evidence base for using corticosteroids to treat HIV-associated immune reconstitution syndrome." 06/01/2007 - "A rapidly progressive, fatal recrudescence of pulmonary Kaposi sarcoma developed in an HIV-infected man who was receiving corticosteroids for treatment of an immune reconstitution syndrome secondary to Mycobacterium avium complex pulmonary infection. " 06/01/2006 - "Most of the evidence supporting the use of corticosteroids (steroids) for immune reconstitution syndrome (IRS) comes from case reports or retrospective series and is of low quality. " 01/01/2008 - "ABSTRACT: BACKGROUND: Kaposi sarcoma (KS) flare may occur following therapy with corticosteroids, as part of the immune reconstitution inflammatory syndrome seen with highly active antiretroviral therapy (HAART), and after rituximab therapy. " Order ALL the reference details at left...

Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART) 01/01/2005 - "Since the advent of HAART, the prognosis for PML has much improved; however, a significant number of patients appear unresponsive to antiretrovirals and some worsen because of the development of immune reconstitution disease. " 04/01/2005 - "This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS). " 10/01/2009 - "An immune reconstitution syndrome (IRS) occurs in between 10% and 25% of patients starting highly active antiretroviral treatment (HAART). " 08/01/2009 - "PURPOSE OF REVIEW: In the era of highly active antiretroviral therapy, immune reconstitution inflammatory syndrome has become well recognized in the HIV-infected population. " 07/17/2009 - "Immune reconstitution inflammatory syndrome (IRIS) after HAART may become manifest in form of aseptic severe leucoencephalopathy. " Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 11/01/2008 - "Recently, immune reconstitution syndrome has also been described in transplant recipients, although information is scarce because of its low incidence. " 10/27/2005 - "Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome." 11/15/2008 - "It is being increasingly recognized that rapid reversal of immunosuppression in transplant recipients treated for cryptococcosis incurs the risk of immune reconstitution inflammatory syndrome, which resembles worsening disease or relapse. " 11/01/2008 - "Here we describe a new case of immune reconstitution syndrome in a liver transplant recipient after successful treatment of cryptococcal meningitis." 06/01/2008 - "These novel signaling pathways, in concert with or independent of Th1/Th2 responses, have potentially important implications for yielding valuable insights into the pathogenesis of immune reconstitution syndrome (IRS) in transplant recipients, for aiding the diagnosis of this entity, and for achieving a balance of immune responses that enhance host immunity while curbing unfettered inflammation in IRS." Order ALL the reference details at left...
3.	Homologous Transplantation (Allograft) 10/27/2005 - "Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome." 12/01/2007 - "Cellulitis revealing a cryptococcosis-related immune reconstitution inflammatory syndrome in a renal allograft recipient." 10/27/2005 - "This study describes the association of allograft loss and immune reconstitution syndrome (IRS) in the course of Cryptococcosis neoformans infection in renal transplant recipients. " Order ALL the reference details at left...
4.	Art Therapy 11/01/2009 - "Immune reconstitution inflammatory syndrome (IRIS) occurs in a subpopulation of HIV-infected patients after the introduction of antiretroviral therapy (ART). " 11/01/2009 - "The immune reconstitution inflammatory syndrome (IRIS) is characterized by clinical deterioration occurring after the initiation of effective antiretroviral therapy (ART) and results from a disordered and exuberant immune response. " 09/01/2009 - "The presentation in this patient suggests immune reconstitution inflammatory syndrome (IRIS) after institution of antiretroviral therapy (ART). " 08/01/2009 - "A significant proportion of patients present with the immune reconstitution inflammatory syndrome (IRIS) after commencing antiretroviral therapy (ART). " 09/01/2008 - "Immune reconstitution inflammatory syndrome (IRIS) is characterised by a clinical worsening of a known condition or the appearance of a new condition after initiating antiretroviral therapy (ART). " Order ALL the reference details at left...
5.	Transplants (Transplant) 06/01/2008 - "Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses." 12/01/2007 - "Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. " 06/15/2005 - "BACKGROUND: We describe an immune reconstitution syndrome (IRS)-like entity in the course of evolution of Cryptococcus neoformans infection in organ transplant recipients. " 06/15/2005 - "An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients." 07/01/2008 - "Some lesser known syndromes such as the immune reconstitution inflammatory syndrome and paraneoplastic neuropathies related with PTLD are increasingly being described and need to be considered in the evaluation of a transplant patient with neurological problems." Order ALL the reference details at left...

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