Immune Reconstitution Inflammatory Syndrome

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161 relevant articles (4 outcomes, 6 trials/studies) found for this Disease

Description: Exuberant inflammatory response towards previously undiagnosed or incubating opportunistic pathogens. It is frequently seen in AIDS patients following HAART.

Also Known As:

Immune Reconstitution Syndrome; Disease, Immune Reconstitution; Immune Reconstitution Syndromes; Reconstitution Disease, Immune; Reconstitution Syndrome, Immune; Reconstitution Syndromes, Immune; Restoration Syndrome, Immune; Syndrome, Immune Reconstitution; Syndrome, Immune Restoration; Syndromes, Immune Reconstitution; Immune Reconstitution Disease; Immune Restoration Syndrome

Relationship Network

Disease Context: Research Results

Immune System Diseases: 1232

Immune Reconstitution Inflammatory Syndrome: 161

Related Diseases

1.	Acquired Immunodeficiency Syndrome (AIDS)
2.	HIV Infections (HIV Infection)
3.	Meningoencephalitis
4.	Infection
5.	Tuberculosis
66 Diseases and 101 more articles analyzed in the Research Interface, order at left...

Experts

1.	Nacher, Mathieu: 3 articles (11/2007 - 03/2006)
2.	El Guedj, Myriam: 3 articles (11/2007 - 03/2006)
3.	Clyti, Emmanuel: 3 articles (11/2007 - 03/2006)
4.	Couppié, Pierre: 3 articles (11/2007 - 03/2006)
5.	Hamill, Richard J: 3 articles (04/2005 - 05/2002)
6.	Visnegarwala, Fehmida: 3 articles (04/2005 - 05/2002)
7.	Shelburne, Samuel A: 3 articles (04/2005 - 05/2002)
8.	Mahamat, Aba: 2 articles (11/2007 - 10/2007)
9.	Carme, Bernard: 2 articles (11/2007 - 10/2007)
10.	Aznar, Christine: 2 articles (11/2007 - 10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Immune Reconstitution Inflammatory Syndrome:

1.	Azithromycin (Zithromax)FDA LinkGeneric 02/01/2002 - "Azithromycin appeared to be protective against disseminated MAC in patients who were either unresponsive or nonadherent to HAART, but it did not prevent the development of immune reconstitution disease due to MAC." Get all the results and reference details, order at left...
2.	Biological Markers (Surrogate Marker)IBA 02/15/2004 - "Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)-infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection" Get all the results and reference details, order at left...
3.	AmBisome (liposomal amphotericin B)FDA Link 08/01/2008 - "Liposomal amphotericin B for a case of intractable cryptococcal meningoencephalitis and immune reconstitution syndrome." 08/01/2008 - "We examined the efficacy of liposomal amphotericin B (L-AMB) for intractable cryptococcal meningoencephalitis in a patient with acquired immunodeficiency syndrome (AIDS) and the presence of immune reconstitution syndrome (IRS) caused by the treatment" Get all the results and reference details, order at left...
4.	Carbon MonoxideIBA 03/01/2007 - "Immune reconstitution inflammatory syndrome in an HIV/TB co-infected patient four years after starting antiretroviral therapy." 09/01/2008 - "A prospective and multi-centre study has allowed us to analyse antibody responses and Mycobacterium tuberculosis clinical isolate genotypes on 24 consecutive HIV-TB co-infected patients treated with Highly Active Antiretroviral Therapy (HAART) who either went on to develop a TB Immune Restoration Syndrome (TB-IRS), or not" 05/01/2001 - "Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'" 10/01/2007 - "We made a retrospective longitudinal study from January 2000 to January 2003 to examine cases of immune reconstitution syndrome (IRS) and its incidence rate in tuberculosis (TB)-human immunodeficiency virus (HIV) co-infected patients" 04/23/2007 - "Immune reconstitution syndrome in tuberculosis and HIV-co-infected patients: Th1 explosion or cytokine storm?" Get all the results and reference details, order at left...
5.	AntigensIBA 05/01/2008 - "The development and severity of the immune reconstitution inflammatory syndrome (IRIS) was dependent on the antigen load at the time of immunosuppression and subsequent bacillary replication during corticosteroid-induced immunosuppression" 01/01/2005 - "This paradoxical worsening is known as the immune reconstitution inflammatory syndrome (IRIS) and it results from reconstitution of the immune system's ability to recognize pathogens/antigens in patients with prior OIs and low CD4+ T-cell counts" 05/01/2008 - "Immune reconstitution inflammatory syndrome (IRIS) is particularly observed after the start of therapy for pathogenic antigens in patients infected with human immunodeficiency virus (HIV) and receiving highly active antiretroviral therapy (HAART)" 01/01/2007 - "The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients initiating antiretroviral therapy (ART) results from restored immunity to specific infectious or non-infectious antigens" 08/01/2006 - "Immune reconstitution syndrome (IRS) is an immune response to an occult opportunistic pathogen or tumor antigen, usually occurs after antiretroviral treatment" Get all the results and reference details, order at left...
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/01/2006 - "Evidence base for using corticosteroids to treat HIV-associated immune reconstitution syndrome." 06/01/2007 - "A rapidly progressive, fatal recrudescence of pulmonary Kaposi sarcoma developed in an HIV-infected man who was receiving corticosteroids for treatment of an immune reconstitution syndrome secondary to Mycobacterium avium complex pulmonary infection" 06/01/2006 - "Most of the evidence supporting the use of corticosteroids (steroids) for immune reconstitution syndrome (IRS) comes from case reports or retrospective series and is of low quality" 01/01/2008 - "ABSTRACT: BACKGROUND: Kaposi sarcoma (KS) flare may occur following therapy with corticosteroids, as part of the immune reconstitution inflammatory syndrome seen with highly active antiretroviral therapy (HAART), and after rituximab therapy" Get all the results and reference details, order at left...
7.	Tuberculin (PPD)IBA 11/15/2008 - "RATIONALE: Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) induced by combination antiretroviral therapy (cART) has been attributed to dysregulated expansion of tuberculin PPD-specific IFN-gamma-secreting CD4(+) T cells" 01/09/2006 - "Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients." Get all the results and reference details, order at left...
8.	SteroidsIBA 04/15/2004 - "Specific antimicrobial therapy, nonsteroidal anti-inflammatory drugs, and/or steroids for managing immune reconstitution syndrome should be considered." 06/01/2006 - "Most of the evidence supporting the use of corticosteroids (steroids) for immune reconstitution syndrome (IRS) comes from case reports or retrospective series and is of low quality" Get all the results and reference details, order at left...
9.	natalizumab (Tysabri)FDA Link 11/01/2006 - "However, immune reconstitution disease is a risk after immune restoration and withdrawal of natalizumab" 07/28/2005 - "Three months after natalizumab therapy was discontinued, changes consistent with an immune-reconstitution inflammatory syndrome developed" Get all the results and reference details, order at left...
10.	infliximab (Remicade)FDA Link 12/01/2007 - "We review the literature on non-tuberculous mycobacterial infections in infliximab-treated patients and report the first case of disseminated Mycobacterium avium complex in an infliximab-treated patient complicated by immune reconstitution inflammatory syndrome" 12/01/2007 - "After the initiation of 4 antitubercular drugs and the discontinuation of infliximab therapy, the patient developed an immune reconstitution syndrome accompanied by enlarged mediastinal lymph nodes and multiple intrapulmonary miliary lesions" Get all the results and reference details, order at left...
46 Drugs and Important Bio-Agents and 59 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART) 01/01/2005 - "Since the advent of HAART, the prognosis for PML has much improved; however, a significant number of patients appear unresponsive to antiretrovirals and some worsen because of the development of immune reconstitution disease" 04/01/2005 - "This study of human immunodeficiency virus (HIV)-infected patients coinfected with Cryptococcus neoformans found that 30% of patients who initiated highly active antiretroviral therapy developed immune reconstitution inflammatory syndrome (IRIS)" 11/01/2008 - "Immune reconstitution inflammatory syndrome is a collection of inflammatory disorders in which a pathologic inflammatory response and clinical deterioration occur during recovery of the immune system after HAART" 10/01/2008 - "Cutaneous manifestations of immune recovery in response to highly active antiretroviral therapy may account for up to 54% to 78% of the clinical presentations of the immune reconstitution syndrome (IRS)" 10/01/2008 - "Immune reconstitution inflammatory syndrome (IRIS) may occur in HIV-infected patients after starting highly active antiretroviral therapy (HAART)" Get all the results and reference details, order at left...
2.	Transplantation (Transplant Recipients) 11/01/2008 - "Recently, immune reconstitution syndrome has also been described in transplant recipients, although information is scarce because of its low incidence" 10/27/2005 - "Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome." 11/15/2008 - "It is being increasingly recognized that rapid reversal of immunosuppression in transplant recipients treated for cryptococcosis incurs the risk of immune reconstitution inflammatory syndrome, which resembles worsening disease or relapse" 11/01/2008 - "Here we describe a new case of immune reconstitution syndrome in a liver transplant recipient after successful treatment of cryptococcal meningitis." 06/01/2008 - "These novel signaling pathways, in concert with or independent of Th1/Th2 responses, have potentially important implications for yielding valuable insights into the pathogenesis of immune reconstitution syndrome (IRS) in transplant recipients, for aiding the diagnosis of this entity, and for achieving a balance of immune responses that enhance host immunity while curbing unfettered inflammation in IRS." Get all the results and reference details, order at left...
3.	Homologous Transplantation (Allograft) 10/27/2005 - "Allograft loss in renal transplant recipients with cryptococcus neoformans associated immune reconstitution syndrome." 12/01/2007 - "Cellulitis revealing a cryptococcosis-related immune reconstitution inflammatory syndrome in a renal allograft recipient." 10/27/2005 - "This study describes the association of allograft loss and immune reconstitution syndrome (IRS) in the course of Cryptococcosis neoformans infection in renal transplant recipients" Get all the results and reference details, order at left...
4.	Art Therapy 06/01/2006 - "Relapse and immune reconstitution syndrome are difficult to distinguish in HIV-infected patients treated with antiretroviral therapy (ART)" 09/25/2005 - "BACKGROUND: With the advent of antiretroviral therapy (ART) cases of immune reconstitution inflammatory syndrome (IRIS) have increasingly been reported" 08/01/2008 - "The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis" 01/01/2007 - "The immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients initiating antiretroviral therapy (ART) results from restored immunity to specific infectious or non-infectious antigens" 07/01/2006 - "Immune reconstitution syndrome resulting from bacille Calmette Guerin (BCG) vaccine occurring 2 weeks to 2 months after institution of antiretroviral therapy (ART) in children has been well documented" Get all the results and reference details, order at left...
5.	Transplants (Transplant) 06/01/2008 - "Novel immune regulatory pathways and their role in immune reconstitution syndrome in organ transplant recipients with invasive mycoses." 12/01/2007 - "Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients" 06/15/2005 - "BACKGROUND: We describe an immune reconstitution syndrome (IRS)-like entity in the course of evolution of Cryptococcus neoformans infection in organ transplant recipients" 06/15/2005 - "An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients." 07/01/2008 - "Some lesser known syndromes such as the immune reconstitution inflammatory syndrome and paraneoplastic neuropathies related with PTLD are increasingly being described and need to be considered in the evaluation of a transplant patient with neurological problems." Get all the results and reference details, order at left...
8 Therapies and Procedures and 123 more articles analyzed in the Research Interface, order at left...

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