Triglyceride and glucose index and the risk of gestational diabetes mellitus: A nationwide population-based cohort study.

Abstract

AIMS:

Pre-pregnancy insulin resistance is one of the main pathophysiologies of gestational diabetes mellitus (GDM). Triglyceride-glucose (TyG) index is a marker of insulin resistance. We aimed to evaluate the association between pre-pregnancy TyG index and GDM in primipara women.

METHODS:

A total of 380,208 women who underwent a Korean national health screening exam within 2 years before their first delivery, between January 1, 2012 and December 31, 2015, were included. The TyG index was calculated as ln [triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2].

RESULTS:

Among the 380,208 primipara women, 17,239 women were diagnosed with GDM (4.53%). Multivariate logistic regression analysis adjusted for risk factors showed a higher odds ratio of 1.73 for GDM (95% CI 1.65-1.81) in the highest quartile than that in the lowest quartile. A 1-SD increase in the TyG index increased the risk of GDM (31%) and GDM requiring insulin therapy (82%) in the fully adjusted model. A 1-unit increase in the TyG index significantly increased the risk of GDM and GDM requiring insulin treatment by 1.81 and 3.69 times, respectively.The impact of a high TyG index on the risk of GDM was more profound in the subjects aged ≥ 35 years, with obesity, with impaired fasting glucose, who are current smokers, and with a family history of diabetes mellitus.

CONCLUSIONS:

Increased pre-pregnancy TyG index is associated with a risk of GDM. Elevation of the TyG index may be an early marker of GDM.

• Authors: Jung A Kim, Jinsil Kim, Eun Roh, So-Hyeon Hong, You-Bin Lee, Sei Hyun Baik, Kyung Mook Choi, Eunjin Noh, Soon Young Hwang, Geum Joon Cho, Hye Jin Yoo
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 171 Pg. 108533 (Jan 2021) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 33157117 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Blood Glucose
• Triglycerides

Topics

• Adult
• Biomarkers (blood)
• Blood Glucose (metabolism)
• Cohort Studies
• Diabetes Mellitus, Type 2 (blood)
• Diabetes, Gestational (blood)
• Female
• Humans
• Pregnancy
• Risk Factors
• Triglycerides (blood)