A survey of hypercalciuria during chemotherapy in acute lymphoblastic leukemia.
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| Abstract | BACKGROUND:
Urolithiasis is an extremely rare complication in childhood acute lymphoblastic leukemia (ALL), and some reports have implicated corticosteroids during chemotherapy as a risk factor for it. However, only a few reports have analyzed urinary electrolytes in this context. METHODS: We retrospectively analyzed 55 patients with ALL who underwent chemotherapy between October 2007 and January 2019. Their median age was 9.3 years (range, 0.3-24.0 years) with 30 males and 25 females. Lineages were B-cell precursor ALL (BCP-ALL) in 42 patients, T-cell in nine and others in four patients. All patients received chemotherapy based on the Berlin-Frankfurt-Münster regimen. RESULTS: Forty-nine out of the 55 ALL patients exhibited hypercalciuria at least once during chemotherapy. Moreover, 36 patients with BCP-ALL, who were receiving identical Berlin-Frankfurt-Münster-based regimens, exhibited significantly high urinary calcium excretion immediately following high-dose glucocorticoid administration. Among the 55 ALL patients, urolithiasis was observed in one patient, a 6-year-old boy with BCP-ALL who developed urolithiasis at reinduction chemotherapy just after cessation of high-dose dexamethasone administration. CONCLUSIONS: Nearly 90% of the ALL patients studied developed hypercalciuria during chemotherapy in strong association with corticosteroid administration.
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| Authors | Daiki Hori, Ryoji Kobayashi, Daisuke Suzuki, Koya Kodama, Masato Yanagi, Satoru Matsushima, Kunihiko Kobayashi |
| Journal | Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 63 Issue 8 Pg. 923-928 (Aug 2021) ISSN: 1442-200X [Electronic] Australia |
| PMID | 33128286 (Publication Type: Case Reports, Journal Article) |
| Copyright | © 2020 Japan Pediatric Society. |
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