Abstract | PURPOSE: The Prostate Health Index is validated for prostate cancer detection but has not been well validated for Gleason grade group 2-5 prostate cancer detection in Black men. We hypothesize that the Prostate Health Index has greater accuracy than prostate specific antigen for detection of Gleason grade group 2-5 prostate cancer. We estimated probability of overall and Gleason grade group 2-5 prostate cancer across previously established Prostate Health Index ranges and identified Prostate Health Index cutoffs that maximize specificity for Gleason grade group 2-5 prostate cancer with sensitivity >90%. MATERIALS AND METHODS: RESULTS: CONCLUSIONS: The Prostate Health Index has moderate accuracy in detecting Gleason grade group 2-5 prostate cancer in Blacks, but Prostate Health Index ≥28.0 can be safely used to avoid some unnecessary biopsies in Blacks.
|
Authors | Rilwan Babajide, Samuel Carbunaru, Oluwarotimi S Nettey, Karriem S Watson, Alfreda Holloway-Beth, Tiffany McDowell, Josef Ben Levi, Marcus Murray, James Stinson, Courtney M P Hollowell, Daniel P Dalton, Le'Andre Moore, Rick A Kittles, Peter H Gann, Edward M Schaeffer, Adam B Murphy |
Journal | The Journal of urology
(J Urol)
Vol. 205
Issue 3
Pg. 718-724
(03 2021)
ISSN: 1527-3792 [Electronic] United States |
PMID | 33103942
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Prostate-Specific Antigen
|
Topics |
- Adult
- Black or African American
- Aged
- Biomarkers, Tumor
(blood)
- Biopsy
(statistics & numerical data)
- Case-Control Studies
- Chicago
- Humans
- Male
- Middle Aged
- Neoplasm Grading
- Prostate-Specific Antigen
(blood)
- Prostatic Neoplasms
(blood, pathology)
- Sensitivity and Specificity
- Unnecessary Procedures
|