Expressions of Fib, IL-12 in Serum of Neonatal Necrotizing Enterocolitis and Their Correlation with Clinicopathological Features.

Abstract

BACKGROUND:

To investigate the expressions of fibrinogen (Fib) and Interleukin-12 (IL-12) in serum of neonatal necrotizing enterocolitis (NEC), and to analyze the correlation between the two and their relationship with clinicopathological features.

METHODS:

Forty two children with NEC treated in Xuzhou Children's Hospital, Xuzhou Medical University Xuzhou, China from 2016-2019 were selected as an observation group and 40 children who underwent physical examination at the same period as a control group. The expression levels of Fib and IL-12 in the serum of two groups were detected by ELISA. The correlation between Fib and IL-12 in the observation group and the correlation among the expressions of Fib, IL-12, the clinicopathological features and common examination indexes of the children with NEC were investigated by Pearson correlation analysis.

RESULTS:

The levels of Fib and IL-12 in the serum of the children in observation group were significantly higher than those in the control group were (P<0.05). There was a significant positive correlation between the levels of Fib and IL-12 in the serum of the children in observation group (P<0.05). The expression levels of Fib, IL-12 were not significantly correlated with sex and age of NEC children, but correlated with vomiting, diarrhea, bloody stool and bradycardia in NEC children (P<0.05). Fib and IL-12 were positively correlated with erythrocyte level (P<0.05) and negatively correlated with platelet level.

CONCLUSION:

The expressions of Fib and IL-12 in the serum of NEC children can objectively predict the severity of NEC.

• Authors: Yiyu Yin, Xiaole Wu, Huaxin Zou, Shixian Li, Zhenfang Qin, Tengfei Zhang, Junhua Cao
• Journal: Iranian journal of public health (Iran J Public Health) Vol. 49 Issue 8 Pg. 1439-1446 (Aug 2020) ISSN: 2251-6085 [Print] Iran
• PMID: 33083320 (Publication Type: Journal Article)
• Copyright: Copyright© Iranian Public Health Association & Tehran University of Medical Sciences.