Necrotizing Enterocolitis

01/01/2017 - "Reduction in necrotizing enterocolitis and improved outcomes in preterm infants following routine supplementation with Lactobacillus GG in combination with bovine lactoferrin."
01/01/2023 - "There were no cases of necrotizing enterocolitis or mortality and no lactoferrin-related adverse effects in these patients. "
09/01/2021 - "Effects of Probiotics and Lactoferrin on Necrotizing Enterocolitis in Preterm Infants."
01/01/2021 - "There was no statistically significant decrease in necrotizing enterocolitis, mortality or neurodevelopmental impairment in lactoferrin supplemented preterm infants. "
02/01/2020 - "Lactoferrin Reduces Necrotizing Enterocolitis Severity by Upregulating Intestinal Epithelial Proliferation."

01/14/2023 - "This study investigated whether delayed receipt of antibiotics in infants with necrotizing enterocolitis (NEC) is associated with disease severity. "
02/27/2022 - "Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study."
01/01/2022 - "The aim of this review was to identify relevant randomized controlled trials (RCTs) and non-RCTs to evaluate the existing knowledge on the effect of antibiotic treatment for infants with necrotizing enterocolitis (NEC). "
11/01/2020 - "Risk of bias in study on early antibiotics and necrotizing enterocolitis."
10/01/2020 - "This study aimed to examine the impact of different antibiotic treatments on necrotizing enterocolitis (NEC) outcomes. "

04/01/2012 - "The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample. "
06/01/2023 - "Paneth cell proteins DEFA6 and GUCA2A as tissue markers in necrotizing enterocolitis."
01/01/2023 - "Among the genetic alterations associated with necrotizing enterocolitis, the -94ins/delATTG polymorphism in NFKB1 gene leads to unregulated activation of the NFKB protein due to an increase in the inherent pro-inflammatory state of the premature intestine. "
11/01/2022 - "In neonatal patients with necrotizing enterocolitis (NEC) the inflammatory response is mediated by a plurality of different proteins. "
05/23/2022 - "fruits prevent necrotizing enterocolitis in rat pups via regulating the expressions of key proteins involved in multiple signaling pathways."

04/01/2005 - "Epidemiology of necrotizing enterocolitis--Part II: Risks and susceptibility of premature infants during the surfactant era: a regional study."
01/01/2023 - "Diabetes in Pregnancy, Surfactant use, and Necrotizing Enterocolitis were also significantly linked to various impairments. "
01/01/2012 - "Canpolat et al.: Effects of enterally administered surfactant in a rat model of necrotizing enterocolitis (Neonatology 2012;102:53-58)."
01/01/2012 - "Is lung surfactant ready 'to protect and to serve' in necrotizing enterocolitis? "
01/01/2012 - "Effects of enterally administered surfactant in a rat model of necrotizing enterocolitis."

12/01/2022 - "Splanchnic-cerebral oxygenation ratio (SCOR), the ratio of splanchnic tissue oxygen (StO2 s) to simultaneously measured cerebral tissue oxygen (StO2 c), has been described as a surrogate to detect impaired splanchnic oxygenation associated with hypoperfusion status such as necrotizing enterocolitis. "
01/01/2016 - "To investigate whether cerebral, liver, and infraumbilical regional tissue oxygen saturation (rSO2) and fractional tissue oxygen extraction (FTOE) could be used to diagnose necrotizing enterocolitis (NEC) and complicated NEC (Bell's stage 3B or death) during its early stages. "
04/01/2015 - "Necrotizing enterocolitis occurred less frequently in the liberal oxygen group. "
04/01/2015 - "Necrotizing enterocolitis occurred more frequently in infants on restricted oxygen (RR, 1.24 [95% CI, 1.05-1.47]). "
11/01/2011 - "To report the use of near-infrared spectroscopic monitoring to recognize mesenteric oxygen desaturations in a preterm neonate with necrotizing enterocolitis as well as the demonstration of reassuring mesenteric tissue perfusion in a twin sibling with an uncomplicated course. "

09/27/2023 - "Based on the existing literature, seven biological functions of gMOS were identified, namely, MOS action as prebiotics, immune modulators, and pathogen traps; their modulation of intestinal cells; protective effect against necrotizing enterocolitis; improved brain development; and positive effects on stressor exposure. "
03/01/2015 - "To test the efficacy of probiotic and prebiotic, alone or combined (synbiotic), on the prevention of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. "
03/01/2015 - "The propre-save study: effects of probiotics and prebiotics alone or combined on necrotizing enterocolitis in very low birth weight infants."
01/01/2023 - "Prebiotic activity of chitooligosaccharides and their ability to alleviate necrotizing enterocolitis in newborn rats."
09/14/2021 - "They serve not only as prebiotics but they exert a protective role against some significant neonatal pathologies such as necrotizing enterocolitis. "

07/01/2014 - "Glutamine downregulates TLR-2 and TLR-4 expression and protects intestinal tract in preterm neonatal rats with necrotizing enterocolitis."
05/01/2004 - "Glutamine had no effect on tolerance of enteral feeds, necrotizing enterocolitis, or growth. "
10/01/2011 - "To examine the impact of oral glutamine (Gln) supplementation on gut integrity and on the incidence of necrotizing enterocolitis (NEC)/septicemia of premature neonates. "
10/01/2011 - "The impact of oral glutamine supplementation on the intestinal permeability and incidence of necrotizing enterocolitis/septicemia in premature neonates."
01/01/2003 - "The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis."

01/01/2021 - "For sROP, significant factors were GA (OR 0.37 and CI 0.27-0.50), SGA (OR 5.65 and CI 2.17-14.92), postnatal corticosteroids (OR 3.81 and CI 1.72-8.40), and perforated necrotizing enterocolitis (OR 7.55 and CI 2.29-24.48). "
12/07/2011 - "For infants born at 22 weeks' gestation, the only outcome that occurred significantly less was death or necrotizing enterocolitis (73.5% with exposure to antenatal corticosteroids vs 84.5% without exposure; AOR, 0.54 [95% CI, 0.30-0.97]). "
09/01/2002 - "Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids."
01/01/2000 - "Prenatal corticosteroid use was associated with decreased risks of all outcomes studied except necrotizing enterocolitis. "
11/01/1990 - "These changes observed in a rat model of necrotizing enterocolitis may explain the decreased incidence of necrotizing enterocolitis in human infants born to mothers who received corticosteroids late in gestation."

02/01/2015 - "In keeping with animal studies, small clinical trials of L-arginine supplementation have shown benefit in reducing necrotizing enterocolitis in premature neonates. "
09/01/2023 - "To What Extent Does Arginine Reduce the Risk of Developing Necrotizing Enterocolitis?"
01/01/2019 - "Enteral l-arginine supplementation for prevention of necrotizing enterocolitis in premature infants."
10/01/2018 - "NEW & NOTEWORTHY Arginine supplementation prevents necrotizing enterocolitis (NEC), the most common gastrointestinal emergency of prematurity. "
10/01/2018 - "Necrotizing enterocolitis (NEC) is associated with low plasma arginine and vascular dysfunction. "

11/01/2011 - "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model. "
11/01/2011 - "Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model."
02/15/2023 - "There were no significant associations between melatonin concentration and necrotizing enterocolitis (P = 0.912). "
08/01/2015 - "Oxidative Stress-Mediated Damage in Newborns with Necrotizing Enterocolitis: A Possible Role of Melatonin."
08/01/2015 - "Therefore, melatonin, besides standard therapies, could be considered as a potentially safe approach to prevent and treat necrotizing enterocolitis in premature infants. "

02/01/2018 - "Stem cell therapy is a promising treatment modality for necrotizing enterocolitis. "
03/01/2013 - "Necrotizing enterocolitis (NEC) is a leading cause of neonatal morbidity and mortality, and preventive therapies that are both effective and safe are urgently needed. "
01/01/2021 - "Human placental-derived stem cell therapy ameliorates experimental necrotizing enterocolitis."
11/03/2023 - "tyrobutyricum may become a promising therapy for NEC.IMPORTANCEThis study sheds light on that treatment with Clostridium tyrobutyricum but not Clostridium butyricum is entitled to protect against necrotizing enterocolitis (NEC) development potentially. "
01/01/2022 - "Our study proposes mechanistic roles of breastmilk feeding and intestinal microbial colonization in postnatal intestinal barrier maturation; these observations are critical toward advancing therapeutics to prevent and treat hyperpermeable gut-associated conditions, including necrotizing enterocolitis (NEC). "

01/01/2022 - "Minimizing the length of hospital stay will be very useful to prevent the occurrence of Necrotizing Enterocolitis."
05/01/2014 - "There was no significant difference in duration of hospital stay or occurrence of necrotizing enterocolitis amongst the two study groups. "
01/01/2023 - "Infants fed exclusive HM before stage 1 palliation (S1P) had lower odds of preoperative necrotizing enterocolitis (odds ratio [OR], 0.37 [95% CI, 0.17-0.84]; P=0.017) and shorter S1P length of stay (rate ratio [RR], 0.87 [95% CI, 0.78-0.98]; P=0.027). "
12/15/2022 - "We used the GRADE approach to assess the certainty of evidence for the following outcomes: failure of ductal closure after the first course of treatment; all-cause mortality during initial hospital stay; and necrotizing enterocolitis (NEC). "
09/24/2021 - "Among 100 patients, 15 were diagnosed with meconium obstruction of prematurity, and five were diagnosed with necrotizing enterocolitis during the hospital stay. "

01/01/2019 - "Role of delayed cord clamping in prevention of necrotizing enterocolitis in preterm neonates: a systematic review."
10/01/2018 - "Compared with immediate clamping, delayed cord clamping was associated with no apparent harm and less suspected necrotizing enterocolitis. "
01/01/2018 - "Impact of umbilical cord milking and pasteurized donor human milk on necrotizing enterocolitis: a retrospective review."
01/01/2018 - "The placental transfusion group showed a trend towards lower incidence of necrotizing enterocolitis. "
12/01/2020 - "In preterm infants, delayed umbilical cord clamping is associated with significant neonatal benefits, including improved transitional circulation, better establishment of red blood cell volume, decreased need for blood transfusion, and lower incidence of necrotizing enterocolitis and intraventricular hemorrhage. "

01/01/2021 - "Secondary outcome: day when start of minimal enteral feeding was feasible, necrotizing enterocolitis incidence, length of hospitalization and whether daily meconium evacuation is more effective than evacuation in presence of clinical symptoms only. "
06/01/2022 - "This study examines the association between pre-operative enteral feeding and subsequent long-term feeding outcomes while also assessing the counterbalancing risk of necrotizing enterocolitis (NEC). "
05/19/2021 - "Enteral Feeding Interventions in the Prevention of Necrotizing Enterocolitis: A Systematic Review of Experimental and Clinical Studies."
01/01/2021 - "The aim of the study was to determine if time to initial enteral feeding (EF) and rate of advancement are associated with necrotizing enterocolitis (NEC) or death. "
01/01/2021 - "Additional studies are needed to assess the impact of earlier full enteral nutrition on rare complications and rates of necrotizing enterocolitis."

01/01/2016 - "Objective The aim of this study was to determine whether very low-birth-weight (VLBW) infants who had feedings withheld during all blood transfusions had a lower incidence of necrotizing enterocolitis (NEC) compared with infants who were fed during transfusions. "
01/01/2023 - "Development of necrotizing enterocolitis after blood transfusion in very premature neonates."
06/01/2022 - " In necrotizing enterocolitis (NEC), blood transfusions (BTs) are a disputed factor concerning the etiology and the outcome. "
10/01/2021 - "Corrigendum to: Canadian Paediatric Society 92nd Annual Conference: Abstracts-79: Withholding Feeds During Blood Transfusion and Risk of Transfusion Associated Necrotizing Enterocolitis (TANEC)."
08/28/2018 - "Key search terms included premature infant, blood transfusion and necrotizing enterocolitis. "