Clinical Significance of CD147 in Children with Inflammatory Bowel Disease.

Abstract

BACKGROUND:

CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation.

OBJECTIVE:

The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD).

RESULTS:

In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147 was increased in intestinal tissue of patients with active IBD compared to that in the control group. What is more, CD147 is involved in intestinal barrier function and intestinal inflammation, which was attributed to the fact that it has an influence on MCT4 expression, a regulator of intestinal barrier function and intestinal inflammation, in HT-29 and CaCO2 cells. Most importantly, serum level of CD147 content is higher in active IBD than that in inactive IBD or healthy control, which could be a biomarker of IBD.

CONCLUSION:

The data suggested that increased CD147 level could be a biomarker of IBD in children.

• Authors: Hongli Wang, Jun Ye, Ruitao Liu, Guanhua Chen, Junhong Zhao, Ling Huang, Fangying Yang, Musheng Li, Shunxian Zhang, Jingxie, Liya Xiong, Huan Chen, Yuxin Xu, Mingmin Su, Yuanwen Xie, Songyu Li, Fengfeng Zheng, Lanlan Geng, Wanfu Xu, Sitang Gong
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 7647181 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 33015178 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Hongli Wang et al.

Chemical References

• Basigin

Topics

• Basigin (blood, metabolism)
• Child
• Epithelial Cells (metabolism, pathology)
• Female
• Humans
• Inflammatory Bowel Diseases (blood, metabolism)
• Intestinal Mucosa (metabolism, pathology)
• Male